Whole blood perfusion bioartificial liver system

Abstract

The invention relates to a whole blood perfusion bioartificial liver system which comprises a blood circulation part and a bioartificial liver circulation part. The blood circulation part comprises a blood input port, a blood pump, a hollow fiber column and a blood feedback port which are sequentially connected. The bioartificial liver circulation part comprises a circulation pump, a constant temperature heater, an oxygenator and a bioreactor which are sequentially connected. An inlet of the circulation pump is connected with an outlet of an outer cavity of the hollow fiber column. A liquid outlet of the bioreactor is connected with an inlet of the outer cavity of the hollow fiber column. The bioartificial liver circulation part is further provided with two bypass pipelines. The whole blood perfusion bioartificial liver system further comprises a liquid input part and a dialyzate drainage part. The whole blood perfusion bioartificial liver system is safe, reliable and efficient, achieves continuous treatment, combines the venous transfusion and part kidney dialysis functions, is comprehensive, and provides effective support for hepatic failure patients.

Description

technical field [0001] The present invention and the medical field particularly relate to a whole blood perfusion bioartificial liver system. Background technique [0002] my country is the country with the most serious liver disease in the world, with more than 1 million new cases of liver failure each year, and about 500,000 liver failure patients die each year due to lack of effective treatment. The mortality rate of liver failure is extremely high, and the effect of conservative medical treatment is not good. As one of the effective treatment methods for patients with severe hepatitis and liver failure, artificial liver support therapy has been recognized all over the world. At present, people are working on the research and development of various artificial livers, especially biological and hybrid artificial livers, hoping that they can replace the damaged liver to perform related functions and help patients recover themselves or wait for liver transplantation. Among t...

AI Technical Summary

Problems solved by technology

Among them, the biological hepatic circulation part is the main body, which is based on the cultivation of liver cells, with the bioreactor as the core carrier, providing functions such as secretion, metabolism, biotransformation and detoxification, and basically includes the following parts: bioreactor, circulation pump, thermostat , oxygenator and circulation pipeline. For patients who need continuous treatment, most of the existing bioreactors for cultivating liver cells are difficult to update or replace. When replacing, the system needs to be shut down, which reduces the efficiency and increases the patient's waiting time and treatment time. prolonged, increasing the risk of system contamination

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