Hybrid artificial liver support system equipped with nano fibre sheet stacked reactor

Abstract

The invention relates to medical facilities, aiming at providing a hybrid artificial liver support system equipped with a nano fibre sheet stacked reactor. The system comprises a plasma separating part, a nonbiological liver circulating part and a biological liver circulating part which comprises a thermostatic gas bath incubator; an extracorporeal circulating pool, a plasma pump and dissolved oxygen which are connected sequeitically and form a circulating system; a temperature testing bottle; and the nano fibre sheet stacked reactor. The system is easily to be amplified so as to improve the defect that cells block a semipermeable membrane easily, the efficiency of material exchange is high and both oxygenation and immunity obstruction function are provided. The reactor has strong function, can be used for biological or hybrid artificial liver, and also used for the cultivation and inducing differentiation of stem cells. The reactor of the system has oxygenation function, thereby saving an oxygenator needing to be equipped independently in normal systems.

Description

technical field [0001] The invention relates to a medical device, in particular to a hybrid artificial liver support system equipped with a superimposed nanofiber mesh reactor. Background technique [0002] As one of the effective treatment methods for patients with severe hepatitis and liver failure, artificial liver support therapy has been recognized all over the world. It includes three categories of non-biological, biological and hybrid artificial livers, of which the latter two are the main international development directions. [0003] The hybrid artificial liver support system usually includes a plasma separation part, a non-biological hepatic circulation part and a biological hepatic circulation part in sequence, and the three parts are connected through a pipeline interface. Among them, the biological hepatic circulation part is the main part, which is based on the cultivation of liver cells, and the bioreactor is the core carrier, which has the functions of biosy...

AI Technical Summary

Problems solved by technology

However, there are the following disadvantages: 1. In the traditional hollow fiber reactor, the fibers are closely arranged in parallel, and there is insufficient space for the growth of liver cells; 2. Only two-dimensional culture can be provided for liver cells, and the three-dimensional culture environment cannot be provided, and the cell activity and function are not good. Good, difficult to organize; 3. Cells tend to accumulate at the bottom of the reactor, and the distribution is uneven; 4. Cells tend to clog the semi-permeable membrane, affecting material exchange

But there are the following problems: 1. Lack of potential safety hazards of immune isolation; 2. Most of the internal pores of the stent are irregular and uneven, which is prone to uneven perfusion, and dead space and dead space are likely to occur in the center and edge of the stent as a whole; 3. The resistance of passing through a large number of scaffolds is large, and the required perfusion intensity is high, which causes the cells to be subjected to large shear forces, making it difficult to amplify

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