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Measuring apparatus and measuring method of cell mechanics

A measuring device and measuring method technology, applied in the direction of measuring devices, biochemical cleaning devices, biochemical equipment and methods, etc., can solve problems such as low measurement efficiency, poor detection accuracy, and limited applications, and achieve wide measurement range and high accuracy. high effect

Active Publication Date: 2015-09-30
SANJIE BIOLOGICAL SCI & TECH BEIJING
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Problems solved by technology

[0004] Atomic force microscopy is a common technique for measuring cell stiffness. However, traditional atomic force microscopy can only detect living cells in a liquid-phase physiological environment and obtain cell images. The technical parameters are strict; due to the piezoelectric ceramic tube scanner The low resonance frequency leads to low measurement efficiency and poor detection accuracy, which limits its further application in high-throughput cell mechanics testing

Method used

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  • Measuring apparatus and measuring method of cell mechanics
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  • Measuring apparatus and measuring method of cell mechanics

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Embodiment Construction

[0029] Specific embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings. It should be understood that the specific embodiments described here are only used to illustrate and explain the present invention, and are not intended to limit the present invention.

[0030] In the present invention, in the absence of a contrary statement, the directional terms mentioned, such as "upper", "lower", "front", "rear", "left", "right", etc., are only for reference The orientation of the graph. Therefore, the directional terms used are for illustration and not for limiting the protection scope of the present invention.

[0031] like figure 1 and figure 2 As shown, the cell mechanics measuring device of the present invention includes a sample tray 1 for placing cell samples; a measurement unit 2 for contacting the cell samples in the sample tray 1 to obtain mechanical parameters of the cell samples; and a control unit 3. Connec...

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Abstract

The present invention relates to a measuring apparatus, and discloses a measuring apparatus and a measuring method of cell mechanics. The measuring apparatus comprises: a sample tray (1) for placing a cell sample, a measuring unit (2) for contacting the cell sample in the sample tray (1) to acquire the mechanical parameters of the cell sample, and a control unit (3) connected with the measuring unit (2) and used for controlling the measuring unit (2) to vertically move according to the mechanical parameters so as to change the contacting degree of the measuring unit (2) and the sample cell and make the measuring unit (2) acquire the mechanical parameters of the cell sample within the contacting degree change period. With the measuring apparatus, the mechanical parameters of the cell can be accurately acquired.

Description

technical field [0001] The invention relates to a measuring device, in particular to a measuring device and a measuring method of cell mechanics. Background technique [0002] The mechanical parameters of cells include cell stiffness, viscosity, etc., and the mechanical parameters are closely related to the state of the cytoskeleton, which plays a key role in the process of cell migration, proliferation, phagocytosis and related molecular signal transduction. The pathophysiological process in various organs and tissues of the human body is accompanied by changes in cell mechanical parameters, especially tumor cells, because their proliferation, migration and metabolism are different from normal cells, and their mechanical parameters are significantly different from those of normal physiological tissues. . For example, the stiffness of cell lines from normal bladder tissue (Hu609 and HCV29) is ten times higher than that of cell lines from bladder cancer tissue (Hu456, T24, B...

Claims

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Application Information

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IPC IPC(8): C12M1/36C12M1/34C12Q1/02
CPCC12Q1/02G01N33/48728
Inventor 冯建涛张悦梁捷杜建英
Owner SANJIE BIOLOGICAL SCI & TECH BEIJING
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