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Use of beta-hydroxybutyric acid or a pharmaceutically acceptable salt thereof

A oxybutyric acid, pharmaceutical technology, applied in the field of medicine, can solve problems such as cardiovascular research has not been done

Active Publication Date: 2018-02-16
ZHUKANG BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, does β-hydroxybutyrate affect ONOO, which plays a key role in diabetes? - , so as to play a cardiovascular protective role has not yet been studied

Method used

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  • Use of beta-hydroxybutyric acid or a pharmaceutically acceptable salt thereof
  • Use of beta-hydroxybutyric acid or a pharmaceutically acceptable salt thereof
  • Use of beta-hydroxybutyric acid or a pharmaceutically acceptable salt thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] In this example, the application of β-hydroxybutyric acid in the preparation of drugs for preventing and treating diabetes and its chronic complications includes: taking a medicinal amount of β-hydroxybutyric acid and mixing it with excipient starch to prepare a powder. The medicinal dosage of β-hydroxybutyric acid is 1-500mg / kg body weight.

Embodiment 2

[0030] In this example, the pharmaceutically acceptable salt of β-hydroxybutyric acid is used in the preparation of drugs for antagonizing oxidative stress and its nitration, including: taking a medicinal amount of β-hydroxybutyric acid sodium salt, and water for injection Mixed to prepare injection.

Embodiment 3

[0032] In this example, the application of β-hydroxybutyric acid in the preparation of a drug for inhibiting weight loss caused by diabetes includes: taking a medicinal amount of β-hydroxybutyric acid and mixing it with water for injection to prepare an injection.

[0033] In other embodiments of the present invention, a medicinal amount of sodium β-hydroxybutyrate may also be mixed with water for injection to prepare an injection. Medicinal dosage is all with embodiment 1. In this field, the preparation of powders and injections is a prior art and will not be repeated here.

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Abstract

The invention discloses a use of β-hydroxybutyric acid or a pharmaceutically acceptable salt thereof, specifically, β-hydroxybutyric acid or a pharmaceutically acceptable salt thereof is used in the preparation of medicines for preventing and treating diabetes and its chronic complications The application of the present invention belongs to the field of medical technology. The present invention utilizes streptozotocin (STZ) to induce a diabetic rat model, and observes its preventive effect on rat diabetes and its chronic complications by subcutaneous injection of β-hydroxybutyric acid. The results show that β-hydroxybutyric acid can inhibit The weight of the rats decreased, and the pathological changes in rats' chronic pancreas, great blood vessels, kidneys, heart, and liver were improved. The present invention uses β-hydroxybutyric acid or a pharmaceutically acceptable salt thereof as a pharmaceutical active ingredient, and combines it with conventional additives in the field of medicine to make a medicine, which can be used to improve diabetes and its chronic complications, and is aimed at anti-oxidative stress and nitro Clinical treatment of diseases caused by chemical damage.

Description

technical field [0001] The invention specifically relates to the application of beta-hydroxybutyric acid or a pharmaceutically acceptable salt thereof in the preparation of medicines for preventing and treating diabetes and its chronic complications, and belongs to the technical field of medicine. Background technique [0002] Diabetes mellitus is an endocrine disease characterized by persistent high blood sugar as its basic biochemical feature. Its harm has become a non-communicable disease second only to cardiovascular and cerebrovascular diseases and malignant tumors. Oxidative stress is considered to be a central link in the development of diabetes and its chronic complications (Sudhahar V, et al. 2013; Hernandez-Mijares A, et al. 2013). In diabetes, the key enzyme of oxidative stress response, inducible nitric oxide synthase (iNOS), is induced to synthesize excess nitric oxide (nitric oxide, NO). NO and O 2 .- Can react rapidly to form peroxynitrite anion ONOO - (pe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/19A61P3/10A61P39/06
Inventor 齐锦生栗彦宁王秀娟刘昆李彬
Owner ZHUKANG BIOTECHNOLOGY CO LTD
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