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Melatonin-containing transdermal patch and preparation method thereof

A technology of transdermal patches and melatonin, which is applied in the direction of medical preparations containing active ingredients, sheet delivery, pharmaceutical formulas, etc., can solve the problem of single dosage form, avoid side effects, overcome short action time, and enhance immunity force effect

Inactive Publication Date: 2015-09-30
马建国
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current dosage form of melatonin products is single, usually oral liquid or oral tablet

Method used

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  • Melatonin-containing transdermal patch and preparation method thereof
  • Melatonin-containing transdermal patch and preparation method thereof
  • Melatonin-containing transdermal patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Such as figure 1 Shown, a kind of transdermal patch containing melatonin, described transdermal patch is made up of substrate 1, colloid 2 containing melatonin and anti-adhesive protective film 3, and described substrate adopts thickness to be 30 microns Polyurethane film, anti-stick protective film adopts 75 micron thick PET film, colloid adopts polyacrylic pressure-sensitive adhesive as matrix, and described colloid is composed as follows by mass percentage:

[0031] Polyacrylic pressure-sensitive adhesive 82%, melatonin 15%, azone 3% (penetration enhancer).

[0032] The method of using the transdermal patch is as follows: cutting the transdermal patch into a certain size, removing the protective film during use, and sticking the exposed colloid surface on the skin.

[0033] The preparation method of the above-mentioned melatonin-containing transdermal patch comprises the following steps:

[0034] (1) Ingredients: take pressure-sensitive adhesive and melatonin by we...

Embodiment 2

[0041] A kind of transdermal patch containing melatonin, its substrate adopts the EVA film that thickness is 30 microns, the anti-adhesive protective film adopts the PET film of 75 microns thick, colloid adopts polyacrylic pressure-sensitive adhesive as matrix, and described colloid Composition by mass percentage is as follows:

[0042] Polyacrylic pressure-sensitive adhesive 91%, melatonin 8%, oleic acid 1% (penetration enhancer).

[0043] In the preparation method of the above-mentioned transdermal patch containing melatonin, the drying temperature in step (3) is 150-160° C., and the rest are the same as in Example 1.

[0044] Cut the prepared transdermal patches into square patches with round corners with an area of ​​5.5cm2, each containing 3mg of melatonin, which is suitable for enhancing immunity and delaying aging. Continuous and steady release of melatonin within 24 hours after patch application.

Embodiment 3

[0046] A kind of transdermal patch containing melatonin, its substrate adopts the EVA film that thickness is 30 microns, the anti-adhesive protective film adopts the PET film of 75 microns thick, colloid adopts polyacrylic pressure-sensitive adhesive as matrix, and described colloid Composition by mass percentage is as follows:

[0047] Polyacrylic pressure-sensitive adhesive 85%, melatonin 13%, lavender essential oil 2% (penetration enhancer).

[0048] In the preparation method of the above-mentioned transdermal patch containing melatonin, the drying temperature in step (3) is 100-120° C., and the rest are the same as in Example 1.

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Abstract

The invention relates to the technical field of transdermal patches, in particular to a melatonin-containing transdermal patch and a preparation method thereof. The transdermal patch comprises a substrate, a melatonin-containing adhesive and an anti-sticking protective film, wherein the melatonin-containing adhesive is a pressure-sensitive adhesive; the melatonin content in the melatonin-containing adhesive is 1-20%. Through the adoption of the melatonin-containing transdermal patch, a user can fall asleep rapidly, the sleeping quality is improved, the immunity is enhanced, and the ageing process is delayed; medicine in the melatonin-containing transdermal patch is applied in a transdermal manner, so that the irritation to a digestive tract and the side effects caused by oral medicine application are avoided, and the use can be safer and more convenient.

Description

technical field [0001] The invention relates to the technical field of transdermal patches, in particular to a transdermal patch containing melatonin and a preparation method thereof. Background technique [0002] Melatonin is an indole hormone secreted by the pineal gland of humans and animals. It has a wide range of physiological activities and can control and coordinate the human immune system, nervous system, endocrine system, and reproductive system. It has anti-stress, anti-lipid Peroxidation, involved in activities such as sedative, hypnotic, analgesic and interest-free effects. At home and abroad, it has been widely used as a health product for anti-aging, enhancing immunity, preventing cardiovascular diseases, cancer and various senile diseases, maintaining normal sexual function, and improving sleep. [0003] Melatonin biosynthesis is regulated by photoperiod. Under the control of the optic nerve, the pineal gland converts tryptophan into 5-hydroxytryptophan, fur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/4045A61P37/04A61P39/06A61P25/20
Inventor 马建国
Owner 马建国
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