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Application of lauric acid modified SOD on labor protection of dye industry and printing and dyeing industry

A technology of labor protection and lauric acid, applied to labor protection in the printing and dyeing industry, lauric acid modified SOD in the field of dye industry, can solve the problems of health protection or labor protection that have not been seen before modifying SOD, and achieve long-lasting activity and preservation Long active time and good heat resistance

Active Publication Date: 2015-09-16
CHINA PETROLEUM & CHEM CORP QINGDAO RES INST OF SAFETY ENG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no report on the application of modified SOD to the health protection or labor protection of workers in the dye industry and printing and dyeing industry.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Synthesis of activated lauric acid modifier

[0026] Take lauric acid, melt it in a 50℃ water bath, add thionyl chloride, the weight ratio of lauric acid to thionyl chloride is 5:1, the reaction pressure is normal pressure, and the rate of adding thionyl chloride is controlled at 2.5 hours. Add 25% of the total amount, and the reaction temperature is 65°C. After 90% of the lauric acid has been converted, the reflux is stabilized for 1 hour. Then it is distilled under reduced pressure to remove excess unreacted substances. Then continue to distill, collect 110-134°C fractions, with a distillation rate of 0.7-0.8 drops / sec. It takes 40 minutes in total, leaving the fraction above 140°C and discarding it. Re-distill the 110-134°C fraction twice, and collect the 124-127°C fraction to obtain the high-purity activated lauric acid modifier, which is stored in the refrigerator for later use.

[0027] (2) Preparation of lauric acid modified SOD

[0028] Dissolve bovine blood SO...

Embodiment 2

[0031] (1) Synthesis of activated lauric acid modifier

[0032] Take lauric acid, melt it in a 60℃ water bath, add thionyl chloride, the weight ratio of lauric acid to thionyl chloride is 7:1, the reaction pressure is normal pressure, and the rate of adding thionyl chloride is controlled at 2.5 hours. Add 25% of the total amount, and the reaction temperature is 135°C. After 80% of the lauric acid has been converted, the reflux is stabilized for 2.5 hours. Then it is distilled under reduced pressure to remove excess unreacted substances. Then continue to distill, collect 110-134°C fractions, with a distillation rate of 0.7-0.8 drops / sec. It takes 35 minutes in total, leaving the fraction above 140°C and discarding it. Re-distill the 110-134°C fraction twice, and collect the 124-127°C fraction to obtain the high-purity activated lauric acid modifier, which is stored in the refrigerator for later use.

[0033] (2) Preparation of lauric acid modified SOD

[0034] Dissolve bovine bloo...

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PUM

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Abstract

The invention discloses an application of lauric acid modified SOD on labor protection of the dye industry and the printing and dyeing industry. A preparation method of the lauric acid modified SOD comprises the following steps that (1) activated lauric acid modifiers are compounded, wherein lauric acid and thionyl chloride are subjected to reaction at 50-140 DEG C, stable returning is performed after at least 80% of lauric acid is converted, and then cut fractions at 124-127 DEG C are collected through reduced pressure distillation, namely the activated lauric acid modifiers; and (2), the lauric acid modified SOD is prepared, wherein ox blood SOD is dissolved in a buffer solution to form an SOD solution, the activated lauric acid modifiers are added into the solution, the mixture is stirred and reacts at 30-50 DEG C and then is quenched to stop reaction, and the lauric acid modified SOD product is obtained. The prepared lauric acid modified SOD has the advantages of easily permeating through the skin and cell membranes compared with natural SOD, being long in activity preservation time and good in heat resistance when stored at normal temperature, being non-toxic and the like. The lauric acid modified SOD is suitable for being applied on labor protection and prevention of occupational dermatosis of staff in the dye industry and the printing and dyeing industry.

Description

Technical field [0001] The invention relates to an application method of lauric acid modified SOD, and specifically relates to the application of lauric acid modified SOD in labor protection in dye industry and printing and dyeing industry. Background technique [0002] 1. Background technology of natural SOD and modified SOD [0003] Superoxide Dismutase (SOD for short) is a type of metal enzymes that exists widely in organisms, and it catalyzes superoxide anion free radicals. The enzymes of the disproportionation reaction are superoxide anion radicals The scavenger is also a medicinal enzyme with important clinical application value. It can treat superoxide anion free radicals Injury related diseases. It is clinically used to treat tumors, inflammation, ischemia-reperfusion injury, oxygen poisoning, Perkins syndrome, Alzheimer's disease, rheumatoid arthritis, aging, various skin diseases, etc. induced by oxygen free radicals. [0004] Natural SOD has the problems of short half-...

Claims

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Application Information

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IPC IPC(8): C12N9/96C12N9/02A61K38/44A61P17/18
CPCA61K38/00A61K38/446C12N9/0089C12N9/96C12Y115/01001
Inventor 巫志鹏葛春涛高艳霞
Owner CHINA PETROLEUM & CHEM CORP QINGDAO RES INST OF SAFETY ENG
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