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Preparation method, pharmaceutical preparation and clinical application of salvianolic acid b, an effective component of traditional Chinese medicine Salvia miltiorrhiza

An active ingredient, salvianolic acid technology, is applied to medical preparations containing active ingredients, drug combinations, drug delivery, etc., which can solve the problems of high cost, difficult to make up, and low total yield, and achieve efficiency improvement and satisfactory Filtration effect, low cost effect

Active Publication Date: 2018-03-27
NANJING CHENXIANG MEDICAL RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The above-mentioned patented technology or process is complex, or time-consuming, or labor-intensive, or consumes coal and energy, or the cost is too high, or it is only a small test, or no yield has been seen
There are two major bottlenecks in the existing technology. One is that the process is cumbersome, and most of them have to be repeatedly processed through the column in 4-5 steps, so it is difficult to realize continuous industrial production; the other is that the stability of salvianolic acid B is relatively poor. and the degradation and conversion rate produced in the separation and purification process are 10% to 15%, and the total yield is relatively low
In particular, the purity of salvianolic acid B obtained by heating, concentrating, separating and purifying under reduced pressure causes degradation of about 5% in the dilute eluent process above 98.5%, which makes the purified product unqualified and is difficult to make up for

Method used

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  • Preparation method, pharmaceutical preparation and clinical application of salvianolic acid b, an effective component of traditional Chinese medicine Salvia miltiorrhiza
  • Preparation method, pharmaceutical preparation and clinical application of salvianolic acid b, an effective component of traditional Chinese medicine Salvia miltiorrhiza
  • Preparation method, pharmaceutical preparation and clinical application of salvianolic acid b, an effective component of traditional Chinese medicine Salvia miltiorrhiza

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1. Routine stirring and extraction with ultra-short time water at room temperature.

[0032] Grind the medicinal material of Danshen, add 10 times the amount of water for the first time, stir and extract at room temperature for 10 minutes, add 4 times the amount of water for the second time, stir and extract at room temperature for 5 minutes, combine the extracts, coarse filter to remove most of the filter residue, and adjust the pH of the filtrate to 3.0 ~4.0, then use cross-flow filtration to fine filter, adjust the pH of the filtrate to 5.5~6.0, and obtain the extract for later use;

[0033] 2. Separation, purification and enrichment of super-macroporous resin

[0034] (1) For the first time through column separation and purification, take the extract and pass through macroporous resin separation No. 2 column, column diameter: column height = 1:8, medicinal material: resin = 1:2, flow rate is 2BV / h; ~10BV of water (flow rate is 4BV~10BV / h), 3~5BV of 1~5% ethanol (fl...

Embodiment 2

[0037] Except for the macroporous resin (chromatographic No. 3) used for separation and purification, it was the same as in Example 1, with a total yield of 71.53% and a purity of 99.17%.

Embodiment 3

[0039] After coarse filtration to remove most of the filter residue, first filter with a 0.45 micron microporous membrane, and then adjust the pH of the filtrate to 3.0 to 4.0. Other proportions and operations are the same as in Example 1. The total yield is 71.62%, and the purity is 99.13%.

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Abstract

The invention relates to a preparation method, a drug preparation and clinical application of a medicine effective component, especially relates to a preparation method of salvianolic acid B from traditional Chinese medicine salvia miltiorrhiza, and a drug preparation and clinical application, and belongs to the traditional Chinese medicine (TCM) technical field. Through use of a new method and a new idea of traditional Chinese medicine chemistry, the goal of being completely green, intelligent and circular economic can be realized, the degradation or transformation of the target compound can be effectively avoided, the preparation method has the advantages of energy conservation and emissions reduction, loss reduction, cost reduction, simple equipment and strong maneuverability, is more suitable for industrial production, and the yield is improved to 65-76% (on the basis of extract content). The present invention also discloses a variety of pharmaceutical acceptable dosage forms and new dosage forms and the clinical application in protecting of myocardial ischemia and anoxia, improvement of microcirculation, reduction of blood viscosity, inhibition of platelet aggregation and thrombosis formation and the like.

Description

technical field [0001] The invention relates to a preparation method, preparation and clinical application of active ingredients of medicines, in particular to a method for preparing salvianolic acid B from the traditional Chinese medicine Salvia miltiorrhiza, a pharmaceutical preparation and its clinical application, and belongs to the technical field of traditional Chinese medicines. Background technique [0002] Cardiovascular and cerebrovascular diseases are one of the common and frequently-occurring diseases of middle-aged and elderly people. Every year, 60 million patients in the world receive heparin therapy (more than 10 million in my country). The effect of using chemical drugs to treat various thromboembolic diseases is not ideal, and it cannot treat both the symptoms and the root causes. Traditional Chinese medicine can treat both the symptoms and the root causes. However, because the quality of Chinese medicine is restricted by many factors such as place of origin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D307/86A61K31/343A61K9/28A61K9/08A61P9/00A61P1/16A61P13/12A61P27/02A61P17/02
CPCA61K9/0019A61K9/0053A61K9/1623A61K9/1635A61K9/1652A61K9/2013A61K9/2031A61K9/28A61K9/5084A61K31/343A61K2300/00C07D307/86
Inventor 陈蓓宁邢为藩吴祖栋余锡荣张璟譞
Owner NANJING CHENXIANG MEDICAL RES
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