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Preparation method of titanium disulfide nanosheet/quantum dot composite mercury ion fluorescent probe

A technology of titanium disulfide and fluorescent probe, applied in the interdisciplinary field of chemistry, physics and materials science, to achieve the effect of novel material selection, low cost and mild method conditions

Active Publication Date: 2015-09-09
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In summary, although the relevant Hg 2+ The preparation method of fluorescent probe has been reported in the literature, but so far there is no Hg based on titanium disulfide nanosheet / quantum dot composite as the main material. 2+ Domestic and foreign literature and patent reports of fluorescent probes

Method used

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  • Preparation method of titanium disulfide nanosheet/quantum dot composite mercury ion fluorescent probe
  • Preparation method of titanium disulfide nanosheet/quantum dot composite mercury ion fluorescent probe
  • Preparation method of titanium disulfide nanosheet/quantum dot composite mercury ion fluorescent probe

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Embodiment 1

[0034] Weigh 20mg TiS 2 The powder was dispersed in 5mL of N-methylpyrrolidone, and ultrasonically treated for 1h to form a suspension. Centrifuge the sonicated suspension and collect the upper dispersion to remove larger particles. Pour the upper dispersion liquid into the flask, and stir the reaction with magnetic force at 100°C for 6h to obtain TiS 2 QDs / nanosheet composite solution. The complex solution was centrifuged, and the upper dispersion was collected as TiS 2 QDs, the lower precipitate is TiS 2 Nanosheets. Add 0.1M phosphate buffer (pH=7.0) to the prepared upper dispersion, stir and react at room temperature for 15 minutes, then add 10 μL ODN (20 μM), incubate at room temperature for 12 hours, then transfer to a dialysis bag for dialysis to remove unreacted TiS 2 QDs, prepared ODN surface-modified TiS 2 QDs. ODN surface modified TiS 2QDs dispersion and TiS 2 Nanosheet dispersion mixed, where TiS 2 QDs and TiS 2 The mass ratio of the nanosheets is 1:2, i...

Embodiment 2

[0037] Weigh 30mg TiS 2 The powder was dispersed in 5mL N-methylpyrrolidone, and ultrasonically treated for 2h to form a suspension. Centrifuge the sonicated suspension and collect the upper dispersion to remove larger particles. Pour the upper dispersion liquid into the flask, and stir the reaction with magnetic force at 120°C for 6h to obtain TiS 2 QDs / nanosheet composite solution. The complex solution was centrifuged, and the upper dispersion was collected as TiS 2 QDs, the lower precipitate is TiS 2 Nanosheets. Add 0.1M phosphate buffer (pH=8.0) to the prepared upper layer dispersion, stir and react at room temperature for 15 minutes, then add 20 μL ODN (20 μM), incubate at room temperature for 24 hours, and then transfer to a dialysis bag for dialysis to remove unreacted TiS 2 QDs, prepared ODN surface-modified TiS 2 QDs. ODN surface modified TiS 2 QDs dispersion and TiS 2 Nanosheet dispersion mixed, where TiS 2 QDs and TiS 2 The mass ratio of nanosheets is 1:...

Embodiment 3

[0040] Weigh 50mg TiS 2 The powder was dispersed in 5mL of N-methylpyrrolidone and treated with ultrasound for 5h to form a suspension. Centrifuge the sonicated suspension and collect the upper dispersion to remove larger particles. Pour the upper dispersion liquid into a flask, and react with magnetic stirring at 150°C for 6 hours to obtain TiS 2 QDs / nanosheet composite solution. The complex solution was centrifuged, and the upper dispersion was collected as TiS 2 QDs, the lower precipitate is TiS 2 Nanosheets. Add 0.1M phosphate buffer (pH=9.0) to the prepared upper layer dispersion, stir and react at room temperature for 15 minutes, then add 50 μL ODN (50 μM), incubate at room temperature for 36 hours, then transfer to a dialysis bag for dialysis to remove unreacted TiS 2 QDs, prepared ODN surface-modified TiS 2 QDs. ODN surface modified TiS 2 QDs dispersion and TiS 2 Nanosheet dispersion mixed, where TiS 2 QDs and TiS 2 The mass ratio of nanosheets is 1:10, inc...

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Abstract

The invention relates to a preparation method of a titanium disulfide nanosheet / quantum dot composite mercury ion fluorescent probe, which comprises the following steps: hydrothermal synthesis is carried out on a raw material titanium disulfide to prepare lamellar-structure TiS2 nanosheets, and an ultrasonic-assisted chemical process is carried out to prepare TiS2 fluorescent quantum dots; a terminal amino group of single-chain oligodeoxyribonudeotide is combined with a carboxy group on the TiS2QDs surface stabilizer molecules to form ODN-modified TiS2QDs, wherein the ODN can be attached to the TiS2 nanosheets under the action of intermolecular force, so that the TiS2QDs indirectly contact the nanosheets to generate fluorescent resonance energy transfer, thereby causing TiS2QDs fluorescent quenching; Hg<2+> can be specifically combined with thymine base on the single chain ODN to form a T-Hg<2+>-T structure, so that the ODN departs from the TiS2 nanosheet surface, and the TiS2QDs also depart, thereby causing fluorescent restoration; and the relationship between the fluorescence intensity and Hg<2+> concentration of the system is fitted to construct the Hg<2+> fluorescent probe based on the titanium disulfide nanosheet / quantum dot composite. The method implements composite construction of the ionic fluorescent probe from the titanium disulfide nanosheet / quantum dot composite and single-chain ODN.

Description

technical field [0001] The invention belongs to the cross field of chemistry, physics and material science, and specifically relates to a method for preparing a titanium disulfide nanosheet / quantum dot composite mercury ion fluorescent probe. Background technique [0002] single-layer or multi-layer titanium disulfide (TiS 2 ) composed of TiS 2 Nanosheet is a new type of two-dimensional layered nanomaterial with graphene-like structure and properties. When its geometric size, especially its thickness, is reduced to the nanoscale range, due to the influence of quantum confinement effects, it will show A series of unique optical and electrical properties. Compared with graphene without bandgap, layered TiS 2 It has a direct bandgap and thus exhibits remarkable photofluorescence. In recent years, TiS 2 Based on their unique photoelectric properties, nanomaterials based on nanomaterials have shown broad application prospects in the fields of new energy, biosensing, photoele...

Claims

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Application Information

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IPC IPC(8): C09K11/02C09K11/67G01N21/64
Inventor 王宗花朱欣欣桂日军金辉杨敏夏建飞
Owner QINGDAO UNIV
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