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A kind of traditional Chinese medicine granule for treating chronic hepatitis B

A technology of chronic hepatitis B and traditional Chinese medicine granules, which is applied in the field of medicine, can solve problems such as lack of a unified consensus and treatment plan, inconsistent clinical efficacy evaluation standards, side effects of patients, etc., and achieve non-toxic side effects, drug safety, and scientific components Effect

Inactive Publication Date: 2018-07-20
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These patients are increasingly aggravated due to recurrent attacks, and patients give up treatment due to serious side effects, and eventually develop liver cirrhosis or even liver failure. solved problem
[0004] In the past 10 years, Chinese traditional Chinese medicine liver disease researchers have conducted a large number of clinical observations and basic research on the treatment of acute and chronic viral hepatitis with traditional Chinese medicine. , syndrome differentiation and treatment combined with interferon therapy, etc., have greatly improved the clinical efficacy of chronic hepatitis B, but a unified consensus and treatment plan have not yet been formed, and the clinical efficacy evaluation standards are not uniform. Therefore, how to determine an effective integrated Chinese and Western medicine treatment plan and It is urgent to clinically validate

Method used

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  • A kind of traditional Chinese medicine granule for treating chronic hepatitis B
  • A kind of traditional Chinese medicine granule for treating chronic hepatitis B
  • A kind of traditional Chinese medicine granule for treating chronic hepatitis B

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] When the present invention is implemented, it can be prepared from the following raw materials by weight: Bupleurum bupleurum 11g, raw astragalus 17g, tangerine peel 13g, coix seed 13g, Clematis 13g, papaya 13g, octopus 13g, Hedyotis diffusa 26g and 13g of Cistanche deserticola, mix the above-mentioned raw medicine together, add water to extract twice, each time add water 12 times the weight of the raw medicine, extract for 2h, filter, combine the filtrate, concentrate under reduced pressure to 60°C with a relative density of 1.25-1.35 The extract is vacuum-dried at 60-70°C and -0.08--0.09Mpa to obtain a dry extract, which is crushed into fine powder for later use; or the filtrate is concentrated under reduced pressure at 60°C to a relative density of 1.08-1.12 The extract is spray-dried at an air inlet temperature of 190±5°C and an outlet air temperature of 80±5°C, and the extract powder is collected for subsequent use; 20-60% of the weight of the extract powder is adde...

Embodiment 2

[0012] When the present invention is implemented, it can also be made from the following raw materials by weight: Bupleurum bupleurum 12g, raw astragalus 20g, tangerine peel 15g, coix seed 15g, Clematis 15g, papaya 15g, octopus 15g, snake tongue diffusa Herb 30g and Herba Cistanche 15g, mix the above raw materials together, add water to extract twice, each time add water 12 times the weight of the raw materials, extract for 2 hours, filter, combine the filtrates, concentrate under reduced pressure to 60°C and the relative density is 1.25-1.35 The extract is vacuum-dried at 60-70°C and -0.08--0.09Mpa to obtain a dry extract, which is crushed into fine powder for later use; or the filtrate is concentrated under reduced pressure to 60°C with a relative density of 1.08-1.12 The extract is spray-dried at an air inlet temperature of 190±5°C and an outlet temperature of 80±5°C, and the extract powder is collected for subsequent use; 20-60% of the weight of the extract powder is added ...

Embodiment 3

[0014] When the present invention is implemented, it can also be made from the following raw materials by weight: Bupleurum bupleurum 13g, raw astragalus 23g, tangerine peel 17g, coix seed 17g, Clematis 17g, papaya 17g, octopus 17g, snake tongue diffusa Herb 34g and Cistanche 17g, mix the above raw materials together, add water to extract twice, each time add water 12 times the weight of the raw materials, extract for 2 hours, filter, combine the filtrates, concentrate under reduced pressure to 60°C and the relative density is 1.25-1.35 The extract is vacuum-dried at 60-70°C and -0.08--0.09Mpa to obtain a dry extract, which is crushed into fine powder for later use; or the filtrate is concentrated under reduced pressure to 60°C with a relative density of 1.08-1.12 The extract is spray-dried at an air inlet temperature of 190±5°C and an outlet temperature of 80±5°C, and the extract powder is collected for subsequent use; 20-60% of the weight of the extract powder is added with m...

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Abstract

The invention relates to traditional Chinese medicine granules for treating chronic hepatitis B, and aims to effectively solve the pharmaceutical problems of chronic hepatitis B. According to the technical scheme for solving the pharmaceutical problems, the traditional Chinese medicine granules are prepared from the following raw medicinal materials by weight: 10-14 g of radix bupleuri, 16-24 g of astragalus membranaceus, 12-18 g of dried tangerine or orange peel, 12-18 g of semen coicis, 12-18 g of radix clematidis, 12-18 g of chaenomeles speciosa, 12-18 g of dried shells of sepia esculenta hoyle, 25-35 g of oldenlandia diffusa and 12-18 g of cistanche deserticola. The raw medicinal materials of the traditional Chinese medicine granules are rich in source, scientific in formula, reasonable in matching and supplementary for one another; the traditional Chinese medicine granules are effective medicines for treating chronic hepatitis B, have the effects of tonifying qi and spleen and clearing heat and removing dampness as the medicines are combined together, are good in treatment effect, safe to use and free of toxic or side effect, and are innovation of medicines for treating chronic hepatitis B.

Description

technical field [0001] The invention relates to the field of medicine, in particular to traditional Chinese medicine granules for treating chronic hepatitis B. Background technique [0002] Chronic viral hepatitis B (chronic hepatitis B for short) is a pathological process with the histological changes of chronic hepatitis caused by hepatitis B virus infection, with a course of more than 6 months and persistent liver cell necrosis and inflammation. my country is a high-prevalence area of ​​hepatitis B virus infection. A considerable number of patients develop severe hepatitis, liver cirrhosis or liver cancer, with poor prognosis and high mortality rate. The rate of hepatitis ranks among the forefront of infectious diseases, and the annual economic loss caused by hepatitis is 50-100 billion. Therefore, this disease is undisputedly the first disease of infectious diseases in my country and seriously endangers people's health. Therefore, the treatment and control of this disease...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8994A61K9/16A61P31/20A61P1/16A61K35/618
Inventor 马素平赵文霞刘光伟孙俊波李艳敏郝尧坤杜铁良
Owner HENAN UNIV OF CHINESE MEDICINE
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