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Chemical compound, crystal form, and preparation methods and applications of chemical compound and crystal form

A technology of compounds and crystal forms, applied in the fields of steroids, organic chemistry, organic chemistry, etc., can solve the problems of unseen compounds, unseen preparation methods and uses, etc.

Active Publication Date: 2015-08-12
CHENGDU FIRST PHARMACEDTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no relevant report on the compound of the present invention and its crystal form, and there is no relevant report on its preparation method and use

Method used

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  • Chemical compound, crystal form, and preparation methods and applications of chemical compound and crystal form
  • Chemical compound, crystal form, and preparation methods and applications of chemical compound and crystal form
  • Chemical compound, crystal form, and preparation methods and applications of chemical compound and crystal form

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Experimental program
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Effect test

Embodiment 1

[0052] (1) Experimental materials:

[0053] ① Medicinal materials

[0054] Motherwort is collected from Wenjiang District, Chengdu, Sichuan, and identified as the whole herb of Lamiaceae Leonurus japonicus Houtt.

[0055] ②Reagents and fillers

[0056] Column chromatography silica gel, 200-300 mesh (reagent grade), purchased from Qingdao Haiyang Silica Gel Desiccant Factory;

[0057] Alkaline silica gel, 300-400 mesh (reagent grade), purchased from Shanghai Shengya Chemical Co., Ltd.;

[0058] TLC silica gel G, GF 254 and H (chemically pure), purchased from Qingdao Haiyang Silica Gel Desiccant Factory;

[0059] Chromatography (neutral) alumina, 100-200 mesh (chemically pure), was purchased from Shanghai Ludu Chemical Reagent Factory.

[0060] MCI gel CHP 20P, 75-150 μm, is a reversed-phase polystyrene resin, purchased from Mitsubishi Chemical Corporation, Japan;

[0061] Sephadex LH-20 glucan gel, purchased from Sweden Amersham company;

[0062] GF 254 Silica gel prepara...

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PUM

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Abstract

The invention disclose a chemical compound as shown in Formula I in the specification, wherein R1, R2 and R3 are selected from methyl, ethyl, propyl, butyl, amyl or hexyl. The invention further discloses a crystal form of the chemical compound, preparation methods and applications of the chemical compound and the crystal form. The chemical compound or the crystal form of the chemical compound has an inhibition effect on cell multiplication of a leukemia cell line MV4-11, and a new choice for screening a drug for treatment or prevention of leukemia in clinic is provided.

Description

technical field [0001] The present invention relates to a kind of compound and its crystal form and its preparation method and use. Background technique [0002] Motherwort was first recorded in "Shen Nong's Materia Medica", formerly known as Chiwei, and was listed as top grade. In "Compendium of Materia Medica", it is called "the holy medicine of the blood family". [0003] Motherwort mainly contains alkaloids, terpenoids, flavonoids, iridoid glycosides, phenylethanol glycosides, volatile oils, peptides and fatty acids, and its activities are mainly alkaloids and diterpenes: [0004] (1) Alkaloids: mainly including stachydrine, leonurine, leonurin and leonurin, etc.; [0005] (2) Diterpene: In recent years, the research on its active ingredients has increased, among which Leoheteronin A and Leopersin G can significantly inhibit the activity of acetylcholinesterase, which has a good prospect in the treatment of Alzheimer's disease; prehispanolone is a platelet antagonist f...

Claims

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Application Information

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IPC IPC(8): C07J9/00A61K31/575A61P35/02
CPCC07B2200/13C07J9/00
Inventor 熊亮彭成周勤梅郭力刘昭华
Owner CHENGDU FIRST PHARMACEDTICAL CO LTD
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