Polyaphron topical composition with vitamin D and corticosteroid, application and manufacturing method thereof

Abstract

A composition suitable for topical application comprising a continuous phase and at least one discontinuous phase, said composition comprising at least one polyaphron dispersion, at least one vitamin D or vitamin D analogue and at least one corticosteroid.

Description

[0001] This application is a divisional application, the international application number of the original application is PCT / GB2008 / 000894, the international application date is March 14, 2008, the Chinese national application number is 200880008496.X, and the entry date for entering the Chinese national phase is 2009 September 15, 2009, the title of the invention is "Multi-microbubble topical composition with vitamin D and corticosteroid". technical field [0002] The present invention relates to compositions for topical application comprising at least one vitamin D or vitamin D analogue and at least one corticosteroid. Background technique [0003] It is known that compositions comprising vitamin D or vitamin D analogs are useful in the treatment of a variety of skin conditions. [0004] For example, EP-B-474,517 discloses the use of compositions containing one or more 1α-hydroxylated-19-nor-vitamin D compounds having a triple bond in the side chain for the treatment of ps...

AI Technical Summary

Problems solved by technology

This is undesirable and may lead to poor patient acceptance

[0016] Another disadvantage of the composition of US-B-6,753,013 is that in order for the composition to provide beneficial results in topical treatments, high levels of vitamin D or vitamin D analogs are required in order to have sufficient vitamin D or vitamin D analogs penetrating into the skin

This is because the composition exhibits poor diffusion through the skin

This is disadvantageous since vitamin D and vitamin D analogs are known skin irritants

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