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Oral analgesic gels for treating sensitivity and tooth pain

A gel and tooth technology, used in dentistry, oral care, organic active ingredients, etc., can solve the problems of unavailability, inability to identify the cause of pain, and undesired side effects.

Active Publication Date: 2015-07-29
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Without a dental examination, the patient may not be able to identify the cause of the pain
Current symptomatic treatment includes medicinal pain relievers (NSAIDs such as aspirin, ibuprofen, or acetaminophen), topical gel anesthetics containing lidocaine or benzocaine, and / or anesthetics such as codeine, but these drugs each have their own limitations in that they may not be available without a prescription, may not have immediate effects, and / or may have undesired side effects
Home remedies provide temporary pain relief, but do not remain on the tooth for extended periods of time and often do not provide controlled delivery of active ingredients or long-lasting pain relief

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Prepare the gel using the following ingredients:

[0062]

[0063]

[0064] Briefly, the carbomer was dispersed in propylene glycol and water, stirred; the surfactant, sweetener, and preservative were then premixed, added, and stirred. The oil blend is then added and the mixture is homogenized. Base is added last, which raises the pH of the mixture and causes the carboxylate groups on the carbomer to ionize, resulting in a thick gel. The above formulations were prepared with different amounts of oil components, the properties of the formulations were observed, and the formulations were applied to the teeth and gums of volunteers:

[0065]

[0066] While none of the formulations were completely unacceptable, the 5% blend appeared to be stable despite the higher oil level, providing good delivery of effective levels of active agent.

[0067] Optimization of Oil Blend Composition : The above 5% oil formulation was then varied using different oil blend composit...

Embodiment 2

[0072] The above gel is further optimized by optionally using small particle silica to provide rapid plugging of the dentinal tubules for sensitivity relief, and / or optionally using additional analgesic oils and / or potassium salts to provide additional pain relief , for the relief of cavity and sensitivity pains. Additional polymeric binders such as polyvinylpyrrolidone (Plasdone® S-630) or methyl vinyl ether / maleic anhydride copolymer (Gantrez®) provide additional matrix support for retention and controlled release of small particles from the formulation Silica or other active agents and / or herbal oils. As in the previous examples, the composition is stabilized by an emulsifying agent and contains other excipients such as sweeteners, wetting agents and preservatives. These leave-on gel formulations are applied directly on the affected tooth surface or along the gum line to provide immediate and long-lasting relief of cavity and sensitivity-related pain. Due to the challenge...

Embodiment 3

[0091] The above gel was further optimized to provide cavitation and sensitivity relief by using arginine instead of sodium hydroxide to neutralize the polymer. Arginine provides long-lasting and soothing cushioning, in addition to forming a complex with available minerals in the mouth to clog dentinal tubules, thereby reducing sensitivity. Arginine was added at the end of the formulation process when it was used in place of the sodium hydroxide of the previous examples for the purpose of neutralizing the anionic polymer and fixing the emulsion as a stable gel.

[0092]

[0093]

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PUM

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Abstract

Disclosed herein are orally acceptable topical analgesic gels comprising a mixture of analgesic oils comprising (a) clove oil and / or eugenol, (b) a cooling agent, and (c) camphor; in an orally acceptable gel base, the gel base comprising an anionic polymer and a basic amino acid, and the analgesic gel providing controlled release of the mixture of analgesic oils following application to a tooth; together with methods of making and using the same.

Description

Background of the invention [0001] Dental pain is most commonly caused by structural damage to the tooth where the nerves of the tooth, usually well protected by dentin and enamel, are exposed to external stimuli, for example as a result of caries, cracked teeth, exposed roots, or erosion of the tooth enamel , and from gum disease, abscesses, or collisions. The severity of toothache can range from chronic and mild to acute and excruciating. Pain can be worsened by chewing or cold or heat. Without a dental examination, the patient may not be able to identify the cause of the pain. Current symptomatic treatment includes medicinal pain relievers (NSAIDs such as aspirin, ibuprofen, or acetaminophen), topical gel anesthetics containing lidocaine or benzocaine, and / or anesthetics such as codeine, but each of these drugs has its own limitations in that they may not be available without a prescription, may not have immediate effects, and / or may have undesired side effects. Home re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61Q11/00A61K47/34A61K36/61A61K47/18A61K47/32A61K31/125
CPCA61K36/185A61K31/085A61K9/0053A61K47/183A61K36/61A61K31/125A61K47/32A61K36/48A61K31/045A61P1/02A61K2300/00A61K9/06
Inventor S.波特尼斯R.苏布拉曼亚姆R.奈尔
Owner COLGATE PALMOLIVE CO
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