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Starch-based vacant capsule and preparation process thereof

A hollow capsule and starch technology, which is applied in capsule transportation, medical preparations of non-active ingredients, and food forming, etc., can solve problems such as insufficient moisture retention, short disintegration time of starch hollow capsules, and low friability, and achieve Easy to have no toxic side effects, short disintegration time, and low friability

Active Publication Date: 2015-07-29
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The starch hollow capsules prepared by this method have short disintegration time and low friability, but the moisture retention is not enough

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Mix 40 parts by weight of high amylose corn starch, 20 parts by weight of glutinous rice starch, 8 parts by weight of pregelatinized starch and 30 parts by weight of deionized water, heat at 45°C for 2 hours, and filter the starch liquid with three layers of fiber membrane ; Dissolve 5 parts by weight of konjac gum in 30 parts by weight of deionized water, add it to the above-mentioned starch liquid, stir while adding, and mix evenly; adopt starch hollow capsule mold to dip in glue, and bake at 35 ° C. dry, and further degummed to obtain starch hollow capsules.

[0032] The starch hollow capsules prepared in Example 1 were analyzed, and the water content of the starch hollow capsules did not change significantly after 24 months, and the disintegration time of the starch hollow capsules in water at 37°C ± 1°C was 4min; the starch hollow capsules were taken 50 grains were placed in a desiccator filled with saturated magnesium nitrate solution for 24 hours, and the friabil...

Embodiment 2

[0034] Mix 50 parts by weight of high amylose corn starch, 30 parts by weight of glutinous rice starch, 10 parts by weight of pregelatinized starch and 30 parts by weight of deionized water, heat at 45°C for 3 hours, and filter the starch liquid with three layers of fiber membrane ; Dissolve 10 parts by weight of konjac gum in 30 parts by weight of deionized water, add it to the above-mentioned starch liquid, stir while adding, and mix evenly; adopt starch hollow capsule mold to dip in glue, and bake at 40 ° C dry, and further degummed to obtain starch hollow capsules.

[0035] The starch hollow capsules prepared in Example 2 were analyzed, and the water content of the starch hollow capsules did not change significantly after 36 months, and the disintegration time of the starch hollow capsules in water at 37°C ± 1°C was 3min; the starch hollow capsules were taken 50 grains were placed in a desiccator filled with saturated magnesium nitrate solution for 24 hours, and the measur...

Embodiment 3

[0037] Mix 60 parts by weight of high amylose corn starch, 40 parts by weight of glutinous rice starch, 10 parts by weight of pregelatinized starch and 30 parts by weight of deionized water, heat at 60°C for 3 hours, and filter the starch liquid with a three-layer fiber membrane ; Dissolve 15 parts by weight of konjac gum in 30 parts by weight of deionized water, add it to the above-mentioned starch liquid, stir while adding, and mix evenly; adopt starch hollow capsule mold to dip in glue, and bake at a temperature of 45°C dry, and further degummed to obtain starch hollow capsules.

[0038] The starch hollow capsules prepared in Example 3 were analyzed, and the water content of the starch hollow capsules did not change significantly after 32 months, and the disintegration time of the starch hollow capsules in water at 37°C ± 1°C was 3min; the starch hollow capsules were taken 50 grains were placed in a desiccator filled with saturated magnesium nitrate solution for 24 hours, a...

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PUM

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Abstract

The invention belongs to the field of medicine preparation and relates to a starch-based vacant capsule and a preparation process thereof. The starch-based vacant capsule comprises components in parts by weight as follows: 40-70 parts of high-amylose starch, 20-60 parts of high-amylopectin starch, 5-15 parts of pregelatinized starch, 5-20 parts of konjac glucomannan and 60-90 parts of deionized water. The starch-based vacant capsule has the characteristics of low cost, good quality and high water-retaining property, meets the standard of Chinese pharmacopoeia, has excellent properties of short disintegration time, low friability and the like, has a better effect in practical application and is suitable for industrial production.

Description

technical field [0001] The invention relates to the technical field of medicine and health products, in particular to a hollow starch capsule and a preparation process thereof. Background technique [0002] At present, empty capsules in my country are mainly prepared from gelatin as the main raw material. Gelatin is the hydrolyzate of connective tissues such as animal skin and bone. Gelatin capsules have good properties such as low friability and short disintegration time limit, but moisture has a great influence on gelatin. Since gelatin capsules themselves contain hydrophilic amino groups and carboxyl groups, they will not The water content is 13%-16%, which makes the hydrophilic substances in the content migrate to the gelatin capsule shell, and the drug with strong hygroscopicity interacts with the capsule under high humidity conditions, causing more drug powder to stick to the inner wall of the capsule , resulting in underutilization of drugs. It will lose water and h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36A23P1/04
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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