Composite starch styptic powder and preparation method thereof

Abstract

The invention relates to a composite starch styptic powder and a preparation method thereof. The preparation method of the composite starch styptic powder comprises the following steps: using potato starch and modified starch as raw materials, emulsifying and cross-linking the potato starch and the modified starch respectively, screening the processed potato starch and the processed modified starch respectively with 150-mesh medicinal sieves, and finally mixing the screened potato starch and the screened modified starch in a certain proportion by a dry powder blending method so as to obtain the composite starch styptic powder. The styptic powder has favorable biocompatibility, good water absorption property and high water absorption speed, can be directly used for general bleeding, deep bleeding and bleeding of parts which are difficult to reach through an operative procedure, is simple and convenient to use, and has good effect of stopping bleeding; the raw materials are free from toxicity and stimulus, wide in sources, low in cost, and simple and feasible in technology, so that the styptic powder has wide clinical application prospects.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a composite starch hemostatic powder and a preparation method thereof. Background technique [0002] War wounds, trauma first aid and surgical operations will all cause bleeding. This problem needs to be solved urgently. The normal human body has the function of hemostasis. Slow and small amount of bleeding can stop bleeding by relying on its own function. The body cannot stop the bleeding by itself, nor can it only rely on ordinary hemostatic bandages to stop the bleeding. If the patient loses too much blood, it may cause shock and even endanger life and health. Currently, the commonly used effective hemostasis method is to use biocompatible absorbable materials to stop bleeding. It is particularly important to provide a safe, effective, easy-to-use, and low-cost hemostatic material in hemostasis such as surgery and first aid. [0003] At present, the clinically ...

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Problems solved by technology

[0003] At present, the clinically used hemostatic materials mainly include fibrin glue, collagen, gelatin sponge and cellulose hemostatic materials. These materials have achieved good results in animal experiments and clinical applications, but there are also some shortcomings: The raw material is derived from animal tissue, which is a foreign protein, which is prone to rejection and has potential sensitization; gelatin absorbs slowly, generally more than 4 weeks, which will increase the risk of wound infection; cellulose, the human body lacks enzymes to degrade it , the degradation time is long, which may bring side effects such as infection to the patient

Modified starch is obtained by modifying the original starch through physical, chemical or biological methods. It has good biocompatibility, stronger water absorption and swelling than the original starch, but the hemostatic effect is still not good.