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Application of traditional Chinese medicine composition of medicine for treating rheumatoid arthritis

A technology of composition and arthritis, which is applied in the application field of traditional Chinese medicine composition in the preparation of drugs for the treatment of rheumatoid arthritis, can solve the problems of poor action selectivity, damage to gastrointestinal mucosa, ulcers, etc., and achieve outstanding substantive characteristics Effect

Inactive Publication Date: 2015-07-15
臧孝国
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, for rheumatoid arthritis, non-steroidal anti-inflammatory drugs (diclofenac, aspirin, etc.) and immunosuppressants (6-mercaptopurine, etc.) are mainly used for treatment, but these drugs have obvious adverse reactions, such as the former damage Gastrointestinal mucosa leads to peptic ulcer, which has poor selectivity and is easy to induce infection, etc.

Method used

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  • Application of traditional Chinese medicine composition of medicine for treating rheumatoid arthritis
  • Application of traditional Chinese medicine composition of medicine for treating rheumatoid arthritis
  • Application of traditional Chinese medicine composition of medicine for treating rheumatoid arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Take 20g of Helicopteris chinensis, 15g of Elena, 12g of Pulmonata, 18g of Fish Eye Grass, and 20g of Wild Buckwheat, add water to decoct twice, the amount of water added for the first time is 10 times the weight of the medicinal materials, and decoct for 2 hours , the amount of water added for the second time is 8 times the weight of the medicinal material, decocted for 1 hour, combined the decoction, concentrated, dried, and pulverized to obtain the traditional Chinese medicine composition granules. Concentration conditions are: 0.07MPa, 60-70 ° C under reduced pressure and concentration to 65 ° C relative density of 1.30. The spray-drying conditions are: the inlet air temperature is 120°C, the outlet air temperature is 80°C, the material temperature is 90°C, the atomization pressure is 0.4 MPa, and the spray speed is 10ml / s.

Embodiment 2

[0016] Embodiment 2: the influence of Chinese medicine composition of the present invention on rat adjuvant arthritis

[0017] 1. Test drug: Prepare the test drug according to the method in Example 1 above.

[0018] 2. Method: Grind Mycobacterium casei (Difco) and mix it with liquid paraffin to make 10 mg / ml, and make Freund's complete adjuvant after autoclaving. Male SD rats were intradermally injected with 50ul of the above-mentioned adjuvant in the right hind paw, and at the same time, injected 50ul intradermally at the tail about 3cm away from the base of the tail. The difference of , represents the degree of swelling. On the 16th day after the adjuvant injection, the left hind paw of the rats was obviously swollen, and the rats were divided into groups according to the degree of swelling and body weight. The experimental group was orally administered with 2, 4, and 8 g crude drug amount / kg of the Chinese medicine composition of the present invention, and the positive con...

experiment example 2

[0026] Experimental example 2, the influence of traditional Chinese medicine composition of the present invention on carrageenan-induced paw swelling of rats

[0027] 1. Test drug: Prepare the test drug according to the method in Example 1 above.

[0028] 2. Method: male SD rats, the experimental group was orally given the Chinese medicine composition of the present invention 2, 4, 8g crude drug amount / kg, the positive control group was orally given diclofenac 10mg / kg, and the control group was given equal volumes of distilled water. After 1 hour, each Subcutaneously inject 0.1 ml of sterilized 1% carrageenan saline into the right hind paw of the rat, measure the volume of the right paw of the rat before and 1, 3 hours after the injection respectively, and express the degree of swelling with the difference before and after the injection.

[0029] Table 3 The effect of traditional Chinese medicine composition of the present invention on carrageenan-induced swelling of rat feet ...

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Abstract

The invention discloses an traditional Chinese medicine composition for the treatment of immunity inflammation. The traditional Chinese medicine composition for the treatment of immunity inflammation is used for preparing medicine for the treatment of rheumatoid arthritis. The traditional Chinese medicine composition is prepared by 20 parts of balanophora polyandra, 15 parts of centaurium pulchellum, 12 parts of herba tripterospermi, 18 parts of dichrocephala auriculata and 20 parts of polygonum convolvulus. Rhinits allergic and diclofenac sodium are used for contrasting. The traditional Chinese medicine composition is good in curative effect and prominent in improvement.

Description

technical field [0001] The invention relates to the new application of the traditional Chinese medicine composition, in particular to the application of the traditional Chinese medicine composition in the preparation of medicines for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis is a clinical common disease and frequently-occurring disease. Rheumatoid arthritis belongs to autoimmune disease and belongs to the category of immune inflammation. At present, for rheumatoid arthritis, non-steroidal anti-inflammatory drugs (diclofenac, aspirin, etc.) and immunosuppressants (6-mercaptopurine, etc.) are mainly used for treatment, but these drugs have obvious adverse reactions, such as the former damage Gastrointestinal mucosa leads to peptic ulcer, which has poor selectivity and is easy to induce infection. Therefore, compounds with well-defined components, controllable quality, safety and high efficiency have potential value in the development of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/70A61P19/02A61P29/00
Inventor 臧孝国
Owner 臧孝国
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