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Frovatriptan succinate tablet and preparation method thereof

A technology for furotriptan tablets and furotriptan, which is applied in the field of medicine, can solve problems such as failure to provide preparations, influence of pharmaceutical agents, and many excipients, and achieves a simple and easy process route, stable quality, and reasonable method selection. Effect

Inactive Publication Date: 2015-07-08
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Patent CN103385876A introduces a solid pharmaceutical composition of furovatriptan succinate. The prescription is simple, but it is a simple tablet and uncoated, which will affect the medicine in storage and other aspects; A film preparation that dissolves rapidly in medium and a preparation method thereof, which is convenient in application but has the problem of more auxiliary materials
[0010] In summary, the existing methods have certain limitations and fail to provide a preparation with good effect

Method used

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  • Frovatriptan succinate tablet and preparation method thereof
  • Frovatriptan succinate tablet and preparation method thereof
  • Frovatriptan succinate tablet and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0023]

Embodiment 2

[0025]

Embodiment 3

[0027]

[0028] The preparation technology of embodiment 1-3 is as follows:

[0029] a. pass the bulk drug through an 80-mesh sieve for subsequent use; weigh the microcrystalline cellulose, lactose monohydrate, silicon dioxide, and sodium starch glycolate of the prescribed amount for subsequent use;

[0030] b. Mix the main ingredient with microcrystalline cellulose, silicon dioxide, sodium starch glycolate; mix with lactose monohydrate;

[0031] c. Add the magnesium stearate of prescribed quantity and mix and then compress into tablets;

[0032] d. Take Opadry dry powder and add it into purified water under stirring, stir until dispersed, and filter until it dissolves evenly; coat with film;

[0033] e. Finished product inspection and packaging.

[0034] According to the Chinese Pharmacopoeia 2010 edition, each embodiment was tested and compared, and the comparison results are shown in Table 1.

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Abstract

The invention provides a frovatriptan succinate tablet and a preparation method thereof and belongs to the technical field of medicines. The frovatriptan succinate tablet is mainly prepared from a main drug, filler, a disintegrating agent, a lubricant, a flow aid and a coating material. The frovatriptan succinate tablet is a selective 5HT1 receptor stimulant which is suitable for treating acute attack of migraine with or without aura of an adult. The frovatriptan succinate tablet provided by the invention is safe and effective, stable in quality, low in cost, convenient to administrate, and the patient compliance is enhanced.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a furovatriptan succinate tablet and a preparation method thereof. The invention provides a safe, effective, stable quality, low cost, convenient administration, strong patient compliance, and can treat migraine tablet. Background technique [0002] Furotriptan succinate, Chinese chemical name: R-(+)3-methylamino-6-carbonamide-1,2,3,4-tetrahydrocarbazole monosuccinate monohydrate, the structural formula is as follows: [0003] [0004] Molecular formula: C 14 h 17 N 3 O·C 4 h 6 o 4 ·H 2 o [0005] Molecular weight: 379.4 [0006] Furotriptan was developed by Ireland's Elan Pharm acutieallne, and was approved by the US FDA in November 2001 in the form of its succinate (1:1) for the acute treatment of migraine with or without aura. Frova. At present, this product is not registered for sale in China. [0007] Furotriptan is a new type of anti-migraine drug that belongs...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K31/403A61P25/06
Inventor 王明刚陈阳生任莉孙桂玉翟翠云刘晓霞汪泓
Owner CP PHARMA QINGDAO CO LTD
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