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Functional grease composition with improvement effects on atherosclerosis

An atherosclerosis and oil composition technology, which is applied in the directions of edible oil/fat, drug combination, organic active ingredients, etc., can solve the problems of difficult to achieve curative effect, less research and development of composition and functional food, etc., and achieves remarkable fat solubility. , strong cholesterol-lowering ability, improve the effect of oxidative stability

Inactive Publication Date: 2015-07-01
INST OF OIL CROPS RES CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Risk factors for cardiovascular and cerebrovascular diseases mainly include lipoprotein metabolism disorder, cholesterol accumulation, oxidative stress, and chronic inflammation. Atherosclerosis (AS) is an important pathological basis and main cause of cardiovascular diseases. For complex diseases with multiple factors, drug intervention with a single function is difficult to achieve good curative effect. It is of great significance to explore early preventive measures for AS. Functional lipid components have great application potential in this field, but related compositions and functions Food research and development is still less

Method used

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  • Functional grease composition with improvement effects on atherosclerosis
  • Functional grease composition with improvement effects on atherosclerosis
  • Functional grease composition with improvement effects on atherosclerosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 68g of linseed oil, 31.95g of sterol α-linolenate and 0.05g of tea polyphenol palmitate, and mix thoroughly to obtain a functional lipid composition that can improve atherosclerosis.

[0023] efficacy experiment

[0024] 1. Experimental materials: take linseed oil (the mass content of α-linolenic acid is 53.6%), sterol α-linolenic acid [purity is 95% (mass)], tea polyphenol palmitate, according to the quality of each raw material The percentages are 68%: 31.95%: 0.05%, mixed evenly, refrigerated for use (ie the product of Example 1).

[0025] 2. Experimental animals and grouping: 42 ApoE knockout mice (ApoE KO) and 14 wild-type C57BL / 6 (wide type, WT) mice under the same genetic background, 4 weeks old, male, weighing 12-15g , purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. After one week of adaptive feeding, WT mice and ApoE KO mice were randomly divided into 3 groups, 14 mice in each group. The abbreviation and intervention method ...

Embodiment 2

[0047] After taking 68g of linseed oil, 31.95g of DHA sterol ester and 0.05g of tea polyphenol palmitate and mixing them thoroughly, a functional lipid composition capable of improving atherosclerosis was obtained.

[0048] The efficacy experiment is the same as in Example 1, and the composition is the product of Example 2.

[0049] Experimental results:

[0050] 1) Oil red O staining results of the whole aorta

[0051] There was no atherosclerotic plaque formation in the whole inner wall of the blood vessel in the mice in the control group. A large area of ​​continuous red atheromatous plaques were seen on the inner wall of the blood vessels of the mice in the model group (HFD group), suggesting that the AS model was successfully established by intervening 18 weeks of HFD in ApoE KO mice. The inner walls of the aortic vessels of the mice in the composition intervention group had very few plaques of atherosclerotic lesions, which were significantly reduced compared with the ...

Embodiment 3

[0062] After taking 68g of perilla oil, 31.95g of DHA sterol ester and 0.05g of tea polyphenol palmitate and mixing them thoroughly, a functional lipid composition that can improve atherosclerosis is obtained.

[0063] The efficacy experiment is the same as in Example 1, and the composition is the product of Example 3.

[0064] Experimental results:

[0065] 1) Oil red O staining results of the whole aorta

[0066] There was no atherosclerotic plaque formation in the whole inner wall of the blood vessel in the mice in the control group. A large area of ​​continuous red atheromatous plaques were seen on the inner wall of the blood vessels of the mice in the model group (HFD group), suggesting that the AS model was successfully established by intervening 18 weeks of HFD in ApoE KO mice. The inner walls of the aortic vessels of the mice in the composition intervention group had very few plaques of atherosclerotic lesions, which were significantly reduced compared with the mice ...

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Abstract

The invention discloses a functional grease composition with improvement effects on atherosclerosis. The functional grease composition with improvement effects on atherosclerosis is characterized by being prepared from the following raw materials in percentage by weight: 1) 68%-90% of linseed oil or perilla oil, 2) 9.99%-31.95% of phytosterols alpha-linolenate or DHA sterol ester, and 3) 0.01%-0.05% of tea polyphenol-palmitate. The composition has the effects of improving the atherosclerosis, restraining over production of atherosclerosis inflammatory factors, improving the anti-oxidant GSH level and restraining the generation of lipid peroxide MDA (methylene dioxyamphetamine), and can be prepared into a soft capsule or used as cooking grease for a patient.

Description

technical field [0001] The invention belongs to the technical field of edible fats and oils, and in particular relates to a functional fat composition which can improve atherosclerosis. Background technique [0002] In modern society, although the average life expectancy of people is continuously increasing, the rapid increase in the incidence of non-communicable chronic diseases (NCCDs) has become an important hindering factor, such as cardiovascular and cerebrovascular diseases, type 2 diabetes, obesity, etc. . According to the World Health Organization's evaluation of many factors affecting human health in recent years, the influence of dietary nutrition factors (13%) is second only to the first genetic factor, and far higher than the role of medical factors. However, there may be problems such as unbalanced nutrient content, anti-nutritional factors, and nutrient loss during storage, processing, and cooking in natural foods, so there is an urgent need for the developmen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K36/55A61K36/535A23D9/007A61K9/48A61P9/10A61K31/575A61K31/353
Inventor 黄凤洪邓乾春许继取黄庆德郑明明万楚筠臧茜茜陈鹏
Owner INST OF OIL CROPS RES CHINESE ACAD OF AGRI SCI
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