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A kind of pharmaceutical composition and its preparation for treating cerebral edema

A composition and a technology for cerebral edema, applied in the field of medicine, can solve the problems of irritation at the injection site, lack of unified opinion, pain, etc., and achieve the effects of low drug side effects, consolidating treatment effects, and reducing damage

Active Publication Date: 2018-03-06
SHANDONG LUOXIN PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 3) Drugs such as hormones are used to damage brain cells, and there is still no unified opinion on the application of large doses of hormones
However, when the dosage of piracetam is high, it can cause local irritation and pain at the injection site

Method used

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  • A kind of pharmaceutical composition and its preparation for treating cerebral edema
  • A kind of pharmaceutical composition and its preparation for treating cerebral edema
  • A kind of pharmaceutical composition and its preparation for treating cerebral edema

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] prescription:

[0041]

[0042] Preparation Process:

[0043] (1) Add the prescribed amount of ethanol into the water for injection (50-60° C.) prepared with a total amount of 50%, and mix well.

[0044] (2) Add buffer to the above solution and stir to dissolve, add the prescribed amount of oxiracetam to it, stir until completely dissolved, adjust the pH value to 5.0, and add water for injection to make up the total amount.

[0045] (3) Add 0.01-0.03% (w / v) activated carbon, heat and stir for 20 minutes, and filter to remove carbon.

[0046] (4) Fine filter with a 0.22um microporous membrane.

[0047] (5) Fill and seal in a glass ampoule, and seal.

[0048] (6) Autoclaving at 121°C for 15 minutes.

[0049] (7) Light inspection and packaging.

Embodiment 2

[0051] prescription:

[0052]

[0053] Preparation process: the same as in Example 1, using glass ampoules for sub-packaging.

Embodiment 3

[0055] prescription:

[0056]

[0057] Preparation process: the same as in Example 1, using glass ampoules for sub-packaging.

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PUM

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Abstract

The invention belongs to the field of medicine and discloses a pharmaceutical composition for treating cerebral edema and a preparation thereof, in particular to a pharmaceutical composition containing oxiracetam and ethanol and an injection thereof. The pharmaceutical composition is used after traumatic brain injury, cerebral hemorrhage, cerebral infarction, meningitis, brain tumor and other injuries and brain surgery, and has a good therapeutic effect on cerebral edema, and compared with the prior art, the drug of the present invention The composition has the advantages of quick effect, obvious effect, convenient use and the like.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a pharmaceutical composition for treating cerebral edema and a preparation thereof, in particular to a pharmaceutical composition containing oxiracetam and ethanol and an injection thereof. Background technique [0002] Cerebral edema refers to the pathological phenomenon that the increase of water in the brain leads to the increase of brain volume, and it is the response of brain tissue to various pathogenic factors. It can cause intracranial hypertension and damage brain tissue. Clinically, it is common in neurological diseases, such as craniocerebral trauma, intracranial infection (encephalitis, meningitis, etc.), cerebrovascular disease, intracranial space-occupying disease (such as tumor), Seizures and systemic diseases such as toxic dysentery and severe pneumonia. The pathogenesis of cerebral edema is very complicated, and there are many related factors, such as blood-brain barrier, m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/4015A61P7/10A61P25/00A61P9/10A61P35/00A61K31/045
Inventor 李明杰刘明霞朱全明杨磊祥
Owner SHANDONG LUOXIN PHARMA GRP CO LTD
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