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Method for establishing quantitative model of auxiliary materials of Chinese medicinal granules

A technology for the quantification of traditional Chinese medicine formula granules and excipients, which is applied in the direction of measuring devices, analyzing materials, and material analysis through optical means, to achieve the effect of low requirements, guaranteed accuracy, and intuitive and simple selection

Inactive Publication Date: 2015-06-24
BEIJING KANGRENTANG PHARMA
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Problems solved by technology

At present, there are few studies on the quantification of excipients by using infrared technology, and there are few reports on the quantification of excipients by near-infrared technology.

Method used

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  • Method for establishing quantitative model of auxiliary materials of Chinese medicinal granules
  • Method for establishing quantitative model of auxiliary materials of Chinese medicinal granules
  • Method for establishing quantitative model of auxiliary materials of Chinese medicinal granules

Examples

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Effect test

Embodiment

[0035] This example is the establishment of an infrared quantitative model for excipients of Salvia miltiorrhiza formula granules, and the specific steps are as follows:

[0036] 1) Select respectively figure 2 , 3 A batch of qualified salvia miltiorrhiza pure extract powder and dextrin, accurately weigh a certain amount of pure extract powder and paste fine powder, mix evenly, make the content of dextrin in the mixture be 0-100%, and prepare a total amount of A total of 200 samples of about 1.00g. Collect the infrared spectra of the above samples, compare the differences in the infrared spectra, and compare the wave number bands 1800cm-1-700cm-1, 1800cm-1-1550cm-1, 1550cm-1-1200cm-1 in the spectrum that are more sensitive to the increase or decrease of excipients , 1180cm-1-1130cm-1, 1130cm-1-945cm-1, 945cm-1-700cm-1 were used as quantitative model parameters, and the difference in the infrared spectra of traditional Chinese medicine formula granules containing different p...

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Abstract

The invention discloses a method for establishing a quantitative model of auxiliary materials of Chinese medicinal granules. The method comprises the following steps: (1) acquiring infrared spectra of the Chinese medicinal granules of auxiliary materials with different proportions, and establishing different model samples so as to form a model database; (2) comparing parameters of the model samples at different sensitive wave number bands, and screening quantitative wave number bands; (3) verifying the wave number section models with relatively excellent parameters, and enabling the wave number bands of the verified result to be corresponding parameters of the quantitative models; and (4) predicting the content of the auxiliary materials of a plurality of Chinese medicinal granules by the quantitative models, and comparing the predicted result with the content of known auxiliary materials so as to determine the parameters of the final quantitative model. The method is used for quantifying the auxiliary materials in the Chinese medicinal granules by utilizing an infrared technique, and the established auxiliary quantitative model can simply and rapidly determine the auxiliary material adding amount in the Chinese medicinal granules, and an important means is provided for evaluating the quality of the Chinese medicinal granules.

Description

【Technical field】 [0001] The invention relates to the technical field of medicine analysis, in particular to an analysis technique for measuring the content of medicine components by infrared rays. 【Background technique】 [0002] Traditional Chinese medicine formula granules are refined through industrialized extraction and concentration, drying, granulation and sub-packaging processes using Chinese herbal decoction pieces that meet the processing requirements on the basis of following the theory of traditional Chinese medicine. According to the physical and chemical properties and process requirements of various traditional Chinese medicines, some traditional Chinese medicine formula granules need to add appropriate excipients during the preparation process. Therefore, the amount of excipients added can affect the quality of traditional Chinese medicine formula granules. At present, there is a lack of monitoring methods for the amount of excipients added in traditional Chin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/3563
Inventor 沈建梅陈敬然
Owner BEIJING KANGRENTANG PHARMA
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