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A production process for improving oil leakage of soft capsules

A production process and soft capsule technology, which is applied in the field of improving the production process of soft capsule oil leakage, can solve the problems of rubber odor, affect product quality, and reduce product quality stability, so as to improve the nature of oil leakage and reduce the probability of oil leakage , Improve the effect of oil leakage

Active Publication Date: 2016-09-14
BY HEALTH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although soft capsules are gradually rising in the pharmaceutical and health care products industry, there are still many problems, such as deformed pills, oil leakage, layered contents, rubber odor, etc., which greatly affect the quality of the product
At present, the technical problem of oil leakage is common in the production process of soft capsules. Since the contents in soft capsules are often highly water-absorbent, during the storage of soft capsules, due to the transfer of moisture from the rubber to the contents, the rubber will Hardening or shrinking, especially at the cracks, are more prone to fine cracks, which will lead to oil leakage during the storage and sales of soft capsules, which will reduce the stability of product quality and increase the rate of defective products

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Put glycerin and purified water into a plastic tank, heat to 60°C, then put in gelatin, and stir evenly, wherein the ratio of gelatin, water and glycerin is 1:1:0.45, heat and stir for 50 minutes to obtain a mixed material; pump the mixed material Vacuum control The vacuum degree is above -0.05Mpa, turn off the vacuum, and open the exhaust valve; pass the glue solution through a 100-mesh filter bag; control the temperature of the glue solution at 60°C and keep it warm for later use; weigh the content of soybean lecithin for later use; The soft capsule content and glue are pressed into soft capsules in a roll mode soft capsule machine, the speed is kept at 3.2 rpm, the temperature of the spray body is kept at 45°C, the thickness of the rubber skin is 0.7mm, and the pressed soft capsules are finalized for 3 hours; dry , the drying method is as follows: the first drying temperature is 25°C, the first humidity is controlled at 26%, and the drying conditions are adjusted afte...

Embodiment 2

[0021] Put glycerin and purified water into the plastic tank, heat to 60°C, then add gelatin, and stir evenly. The ratio of gelatin, water and glycerin is 1:0.92:0.42, and the ratio of skin gelatin and bone gelatin in gelatin is 55:45 , heat preservation and stirring for 50 minutes to obtain the mixed material; vacuumize the mixed material to control the vacuum degree above -0.05Mpa, turn off the vacuum, and open the exhaust valve; pass the glue through a 100-mesh filter bag; control the temperature of the glue at 60°C and keep it warm for later use ; Weigh the content of soybean lecithin, set aside; Press pills: Press the soft capsule contents and glue solution into soft capsules in a rolling mode soft capsule machine, keep the rotating speed at 3.2 rpm, keep the temperature of the spray body at 45°C, and the thickness of the rubber skin It is 0.7mm, and the two sheets of rubber that accompany the rotation of the mold, when in contact, the contact surface is a slope, and the s...

Embodiment 3

[0023](1) Sol: Accurately weigh gelatin, purified water and glycerin according to 1:0.92:0.42, wherein the ratio of skin gelatin and bone gelatin in gelatin is 55:45; (2) put purified water and glycerin into the plastic tank, When the temperature in the plastic tank reaches 70-80°C, add gelatin particles; (3) cook the plastic tank under negative pressure for 30-70 minutes, and the temperature during the cooking process does not exceed 75°C; (4) After confirming that the gelatin is completely melted, mix Continue to stir the solution for 10 minutes and then turn on the vacuum pump to vacuum the glue mixture material for 10-30 minutes, the vacuum degree is above -0.08Mpa, until the glue has no bubbles, turn off the vacuum and open the exhaust valve; (5) Filtration: deflate After the glue passes through a 100-mesh filter bag; stand still: release the filtered glue and place it in a rubber storage barrel to stand still, keep the glue at 60°C, and reserve it; (6) prepare the content...

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Abstract

The invention relates to a production technology for improving oil leakage of soft capsules. The technology effectively solves the problem of easy oil leakage of soft capsules by adjusting the drying mode, a ratio of gelatin to glycerin to water, and the rubber thickness. The quality of soft capsules obtained through the technology disclosed in the invention is stable. The technology can be widely used to prepare liquid calcium, soybean lecithin, fish oil, propolis, squalene, natural vitamin E and other soft capsules.

Description

technical field [0001] The invention relates to the technical field of health care products, in particular to a production process for improving oil leakage of soft capsules, and the soft capsules produced by the process can effectively solve the problem of oil leakage of soft capsules. Background technique [0002] Soft capsules are capsules in which the contents or medicines are mixed with suitable auxiliary materials and then sealed in soft capsule materials by dripping method or pressing method. Soft capsules have the following advantages: 1. It is beneficial to the absorption of active substances. The drug is wrapped in a hydrophilic gelatin skin and disintegrates in the digestive tract soon after oral administration. It can improve the bioavailability of drugs, improve the stability of drugs that are prone to hygroscopic instability and oxidation, have a good taste, can cover the bad smell of volatile components in drugs, and are easy to take. At present, the common h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23P10/30A61K9/48
Inventor 殷光玲
Owner BY HEALTH CO LTD
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