A kind of tumor drug targeting carrier and its application

Abstract

The invention discloses a tumor drug targeting vector, a coupling method of the vector and an anti-tumor drug and the formed anti-tumor drug. The tumor drug targeting vector is foot and mouth disease virus-like particles. The chemical coupling method of the tumor drug targeting vector and the anti-tumor chemical drug includes the steps that a tumor drug vector is activated through chemical coupling reagents of carbodiimide (EDC) and N-hydroxysuccinimide (NHS), and the rumor drug vector is then coupled with other anti-tumor drugs. The anti-tumor drug can be specifically combined with an integrin receptor over expressed by the surfaces of tumor cells, targeting modification does not need to be conducted on the surfaces, and the targeting treatment effect of anti-cancer drugs can be improved.

Description

technical field [0001] The invention relates to an anti-tumor drug targeting carrier, the coupling of the carrier and the anti-tumor drug, and the formed anti-tumor drug. Background technique [0002] Malignant tumors have become one of the important diseases that threaten human health today. There are more than 10 million new cancer patients in the world every year. Cancer control has become the focus of global health strategies. Chemotherapy is still one of the main means of treating malignant tumors. Traditional chemotherapy mainly uses chemical drugs, such as the antineoplastic drug doxorubicin (DOX), to inhibit the proliferation of tumor cells and kill tumor cells. However, most chemotherapeutic drugs are not specific, and will damage normal tissues while inhibiting tumor tissues. Therefore, they have toxic and side effects that cannot be ignored, such as decreased immune function, bone marrow suppression, heart and liver toxicity, etc. [0003] In order to overcome th...

AI Technical Summary

Problems solved by technology

Chemotherapy is still one of the main means of treating malignant tumors. Traditional chemotherapy mainly uses chemical drugs, such as the antineoplastic drug doxorubicin (DOX), to inhibit the proliferation of tumor cells and kill tumor cells. However, most chemotherapeutic drugs are not specific, and will damage normal tissues while inhibiting tumor tissues. Therefore, they have toxic and side effects that cannot be ignored, such as decreased immune function, bone marrow suppression, heart and liver toxicity, etc.

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