Self-assembled nano targeted carrier drug for precisely curing lung cancer and preparing method thereof

Abstract

The invention relates to the field of medical treatment and discloses a self-assembled nano targeted carrier drug for precisely curing lung cancer and a preparing method thereof. The preparing methodcomprises the following preparing processes that 1, polypeptide powder is dissolved in deionized water, so that a polypeptide solution is prepared; 2, chitosan and erlotinib hydrochloride are added tothe polypeptide solution, so that a pregelatinized gel is prepared; 3, the pregelatinized gel is frozen and smashed to a nano grade, a saline solution is added to the pregelatinized gel so that the pregelatinized gel can be gelatinized, the gelatinized gel is frozen and dried, and thus self-assembled nano particles are prepared, namely the nano targeted carrier drug for precisely curing lung cancer. According to the preparing method, the chitosan, the erlotinib hydrochloride and the polypeptide are prepared into the pregelatinized gel, and self-assembling is further conducted, so that the nano carrier drug is prepared. The nano targeted carrier drug for precisely curing lung cancer is not easily degraded by biological enzymes, has excellent stability, can effectively improve the targetedtreatment effect of the erlotinib hydrochloride under the premise of controlled release, and can be widely applied to lung cancer treatment.

Description

technical field [0001] The invention relates to the medical field, and discloses a self-assembled nano-carrier drug for targeted and precise treatment of lung cancer and a preparation method thereof. Background technique [0002] In recent years, cancer is a disease that seriously affects human health. Traditional anticancer drugs attack normal cells while killing tumor cells. How to release anticancer drugs only in tumor tissue without affecting normal cells is a hot issue that needs to be solved urgently. Targeted precision therapy has become a key technology in cancer treatment. At this stage, sustained-release drugs are mainly prepared through microcapsules and nanogels, but it is difficult to achieve the purpose of release at the tumor site due to easy drug leakage and drug leakage. [0003] At present, in targeted therapy, targeted nano-drug carriers have emerged, such as carbon nanotubes, nanoparticles, and mesoporous silica, which have been used as nano-drug carrie...

AI Technical Summary

Problems solved by technology

[0007] According to the above, although erlotinib, which is used in the treatment of lung cancer in the existing scheme, has a good targeted therapy effect, it is unstable in delivery. Therefore, improving the stability of the drug and preventing the drug from being degraded by biological enzymes is the key to improving drug control. The key to the role of release and targeted therapy, the present invention proposes a self-assembled nano-carrier drug for lung cancer targeted precision therapy and its preparation method, which can effectively solve the above technical problems

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