Method for preparing medical bone gelatin by biological enzyme method

Abstract

The invention discloses a method for preparing medical bone gelatin by a biological enzyme method and relates to a bone gelatin preparation process, particularly a process for preparing top grade medical bone gelatin by the biological enzyme method by taking animal bone meal such as pig bone meal, ox bone meal and the like as raw materials. The method is characterized by comprising the following steps: crushing; mixing slurry; dropping and soaking acid; washing; carrying out enzymolysis; re-cleaning; deactivating enzyme and extracting gelatin; flocculating and filtering; ultra-filtering and concentrating; and instantaneously sterilizing and the like. By taking small particle bone meal as the raw material, an excision enzyme method gelatin process of bone meal demineralization is accomplished under low acid concentration, and the process is verified successfully on a production line of producing 1 ton of gelatin one day. The production period is shortened to 2-3 days, the generated organic waste water is reduced by 80%, the production efficiency is improved to a great extent, and gelatin clean production is achieved. The produced and prepared gelatin product is high in jelly strength and good in viscosity and transparency and reaches the national standard of level A top grade medical gelatin by 100%.

Description

technical field [0001] The invention relates to a bone gelatin preparation process, in particular to a process for preparing high-grade medical bone gelatin using a biological enzymatic method using animal bone powder such as pig bones and bovine bones as raw materials. Background technique [0002] my country is a big producer of bone gelatin. The major gelatin factories in the country basically still use the traditional liming process. The production cycle is as long as 60 days. The water consumption per ton of gelatin is 800-1000 tons. The proportion of total gelatin) is about 30%. With the continuous expansion of production scale and increasingly intensified market competition, defects such as high energy consumption, low efficiency, large water consumption, and low good glue rate in traditional processes have become increasingly prominent, making the profit of bone gelatin production lower and lower. [0003] In the 1950s, researchers began to study the rapid preparatio...

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Problems solved by technology

[0004] Among the current patents related to the preparation of bone gelatin by biological enzymatic methods, such as the patent with publication number CN1473901 A, a "method for preparing gelatin by enzymatically degrading collagen" is disclosed. The gelatin is prepared from undemineralized bone particles, but the bone Minerals in the granules will be leached out during the gelatin extraction process and remain in the gelatin, causing the ash content of the gelatin product to be substandard; the patent with the publication number CN103333939 A discloses "a method for preparing gelatin by compounding alkaline enzymes to degrade collagen fibers ", gelatin was prepared from osteoin obtained from the demineralization of large bone granules (2-5 cm), and the demineralization of large bone granules was carried out with high-concentration hydrochloric acid, which severely damaged the internal peptide chains of collagen fibers, resulting in subsequent enzymatic The solution process is difficult to control, and the gelatin product viscosity is too low (2-4 mPa s), it is difficult to meet the national standard of high-grade medical bone gelatin; the patent with the publication number CN102329843 A discloses "a method for preparing gelatin by enzymatic method", using Concentrated phosphoric acid about 1 times the volume of bone powder is put into the bone powder for demineralization at one time, and calcium hydroxide is used for flocculation. The residual calcium salt will easily cause the ash content of gelatin products to fail to meet the standard. Compared with hydrochloric acid, phosphoric acid is expensive, and the production cost of the process is lower. High, difficult to promote industrialization

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