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New application of Kadsura conccinea fruit extract as phytoestrogen

A technology of phytoestrogens and extracts, applied in plant raw materials, medical preparations containing active ingredients, plant/algae/fungus/moss components, etc., can solve the problems of black tiger fruit phytoestrogens and other problems

Inactive Publication Date: 2015-05-13
怀化医学高等专科学校
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In the existing research reports on black tiger fruit, there is no report that black tiger fruit has the effect of phytoestrogens

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Preparation of black tiger fruit extract:

[0021] Take 5 kg of dried black tiger fruit, add 40 L of 95% ethanol, reflux and extract twice at 55°C for 2 hours each time, filter, combine the filtrates, concentrate and dry in vacuo. The resulting dark brown solid was 184.2 g, with a yield of 3.7%.

[0022] The dose of the above-mentioned black tiger fruit extract is 12-120 mg per kilogram of body weight per person per day.

Embodiment 2

[0024] Preparation of black tiger fruit hard gelatin capsules:

[0025] components Mass (mg / capsule) Black Tiger Fruit Extract 100～200 Starch, DF 0～50 flowable starch powder 0～50 Polysiloxane fluid 350 centimeter pool 0～15

[0026] The dosage form is prepared according to the above-mentioned proportioning method according to the conventional method of pharmacy.

Embodiment 3

[0028] Preparation of Black Tiger Fruit Tablets:

[0029] components Mass (mg / tablet) Black Tiger Fruit Extract 100～200 microcrystalline cellulose 50～100 fumed silica 10～100 stearic acid 5～15

[0030] The dosage form is prepared according to the above-mentioned proportioning method according to the conventional method of pharmacy.

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Abstract

The invention discloses new application of a Kadsura conccinea fruit extract as phytoestrogen. In order to overcome the shortcomings of lack of study on Kadsura conccinea fruit containing phytoestrogen, its effect and the like in current Kadsura conccinea fruit research reports, through the influence of the Kadsura conccinea fruit extract on breast cancer MCF-7 cell proliferation experiment, estrogen receptor binding experiment, and rat uterus weight experiment and the like, the invention for the first time proves that the Kadsura conccinea fruit extract contains phytoestrogen, can directly excite estrogen receptors, promote rat uterine growth and increase rat uterine weight, and can make the estrogen level in animals rise. The Kadsura conccinea fruit extract has the effect of phytoestrogen, and is a very promising natural drug for treating and / or preventing estrogen secretion shortage related diseases. The Kadsura conccinea fruit extract involved in the invention can be applied as a drug for treatment of estrogen secretion shortage related diseases.

Description

technical field [0001] The invention relates to a new application of the black tiger fruit extract and its preparation in the field of medicine, in particular to the new application of the black tiger fruit extract as a phytoestrogen. Background technique [0002] Decreased levels of estrogen in women can lead to conditions such as menstrual disorders, amenorrhea, infertility, and perimenopausal syndrome (also known as climacteric syndrome in women). At present, the clinical treatment of various diseases caused by estrogen deficiency mainly adopts estrogen replacement therapy, and the drugs used are mainly synthetic estrogen analogs, such as nilestriol and premarin. [0003] Studies have found that synthetic estrogen has a series of serious side effects, such as hypercoagulability, hypertension, edema, etc., and can increase the risk of breast cancer and endometrial cancer. Therefore, there is an urgent need to develop a new type of drug with good curative effect and few ad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/57A61P5/30
Inventor 吴卫华汪冶郑钦方肖聪颖
Owner 怀化医学高等专科学校
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