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Compositions and methods for the treatment of metabolic syndrome

A composition and compound technology, which is applied in metabolic diseases, drug combinations, pharmaceutical formulations, etc.

Inactive Publication Date: 2015-05-06
CELLIXBIO PTE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Despite strong experimental evidence that oxidative stress can determine the onset and progression of advanced diabetic complications, there is controversy as to whether increased oxidative stress is simply associated with the metabolic syndrome rather than causal

Method used

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  • Compositions and methods for the treatment of metabolic syndrome
  • Compositions and methods for the treatment of metabolic syndrome
  • Compositions and methods for the treatment of metabolic syndrome

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Embodiment Construction

[0033] definition

[0034] As used herein, the following terms and phrases shall have the meanings set forth below. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art.

[0035] The compounds of the present invention may exist in the form of pharmaceutically acceptable salts. The compounds of the invention may also exist in the form of pharmaceutically acceptable esters (ie, the methyl and ethyl esters of the acids of formula I to be used as prodrugs). The compounds of the invention may also be solvated, ie hydrated. Solvation may act or occur during the manufacturing process, ie due to the hygroscopic nature of the initially anhydrous compound of formula I (hydration).

[0036] Compounds that have the same molecular formula but differ in the nature or in the sequence in which their atoms are joined or in the arrangement of their atoms in space are termed "isomers". Isomer...

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Abstract

The invention relates to the compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I), and methods for the treatment of metabolic syndrome may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of hyperuricemia, gout; dyslipidemia, obesity, urea cycle disorders, hyperglycemia, insulin resistance, diabetes mellitus, diabetes insipidus, type 1 diabetes, type 2 diabetes, microvascular complications,.macrovascular complications, lipid disorders, prediabetes., obesity, arrhythmia, myocardial infarction, stroke, neuropathy, renal complications, hypertriglyceridemia, cardiovascular complications, and post prandial hyperglycemia.

Description

[0001] priority [0002] This application claims the benefit of Indian Provisional Patent Application No. 1835 / CHE / 2012 filed on May 10, 2012, the entire disclosure of which is relied upon for all purposes and is incorporated by reference in its entirety In this application. technical field [0003] The present disclosure generally relates to compounds and compositions useful in the treatment of metabolic syndrome. More specifically, the present invention relates to the treatment of a subject with a pharmaceutically acceptable dose of a compound, crystal, solvate, enantiomer or stereoisomer, ester, salt, hydrate, prodrug, or mixtures thereof. Background technique [0004] The multifaceted metabolic syndrome is defined as a number of major metabolic disorders that increase the risk of cardiovascular disease (CVD) - still the most important cause of death in the West. It is also known as insulin resistance syndrome, syndrome X, metabolic disorder syndrome, or the death quart...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C23/00C07C22/00A61K31/381A61K31/429A61K31/11A61K31/12A61K31/192A61P3/02A61P3/04A61P3/06A61P3/08A61P9/00A61P9/10A61P13/00A61P13/12
CPCA61K31/198A61K31/202A61K31/216A61K31/385A61P3/00A61P3/02A61P3/04A61P3/06A61P3/08A61P3/10A61P9/00A61P9/06A61P9/10A61P13/00A61P13/12A61P19/06A61P25/00A61P43/00C07C57/02C07C59/68C07D339/04
Inventor M·坎杜拉
Owner CELLIXBIO PTE LTD
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