Biodegradable physical hydrogel capable of rapid gelation in situ and preparation method thereof

Abstract

The invention relates to the technical field of biodegradable high-polymer materials, and aims at providing a biodegradable physical hydrogel capable of being rapidly gelatinized in situ and a preparation method of the biodegradable physical hydrogel. The biodegradable physical hydrogel capable of being rapidly gelatinized in situ is composed of a component A aqueous solution and a component B aqueous solution. The preparation method specifically comprises the following preparation steps: by taking stannous octoate as a catalyst, synthesising a component A and a component B through ring-opening polymerization respectively; dissolving the prepared component A and component B in water respectively, then mixing to form a mixed solution and carrying out an oscillation treatment to obtain a stable physical cross-linked hydrogel. The preparation process of the hydrogel disclosed by the invention is simple, and the gelatinization time and the mechanical strength of the hydrogel can be adjusted by changing the ratio of the component A to the component B and a total polymer concentration; the prepared hydrogel is biodegradable, capable of being metabolised by a human body, capable of being rapidly gelatinized in situ without external stimulation, and capable of being used in the biomedical fields of medicine carriers, tissue engineering and the like.

Description

technical field [0001] The invention relates to the technical field of biodegradable polymer materials, in particular to a biodegradable physical hydrogel that can be quickly gelled in situ and a preparation method thereof. Background technique [0002] Hydrogel is a kind of hydrophilic polymer system with three-dimensional network structure, which is widely used in biomedical engineering because of its structural properties similar to biological tissues. In situ hydrogel means that the gel is administered in a solution state, and a solution-gel phase transition occurs at the receptor site. According to different cross-linking mechanisms, it can be divided into chemical cross-linking and physical cross-linking hydrogels. Physically cross-linked hydrogels do not involve chemical reactions in the gel formation process, and the cross-links between molecular chains are formed by non-covalent physical forces (such as hydrophobic interactions, van der Waals forces, hydrogen bonds...

AI Technical Summary

Problems solved by technology

[0004] However, such block copolymers of a single component have the following problems: 1) When the copolymer composition or molecular weight exceeds a certain value, it will be completely soluble in water or completely (partially) precipitated, so that the sol-gel transition disappears and loses In-situ gelation performance; 2) The gelation transition can only occur under specific stimulus responses (such as temperature, pH value, etc.), so the regulation of the gelation process is more complicated; 3) The in-situ gelation speed is relatively fast. Slow, it takes a certain amount of time, which may affect its biomedical application, for example, it may cause sudden release of drugs in drug release; 4) Its degradation rate and degradation kinetics need to be adjusted by changing the polymer copolymer composition, which is more complicated

However, the PLLA-PEG-PLLA / PDLA-PEG-PDLA mixed hydrogel still has some disadvantages, such as the need for a specific temperature stimulus response to the gelation transition, and the in situ gelation speed is slow, taking 10 to 30 minutes time

Images