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Methods of using polymers

A technology of polymers and species, applied in the direction of drug devices, chemical instruments and methods, drug combinations, etc., can solve problems such as ineffectiveness in the treatment of toxins, lack of antidote, exposure, etc.

Active Publication Date: 2015-04-29
CYTOSORBENTS CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, antidotes for many toxins have not been developed, and the amounts of some antidotes may be too small to be effective in treating some toxin exposures

Method used

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  • Methods of using polymers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-18

[0084] Eighteen porous polymeric adsorbents characterized by their pore structure and their synthesis are described in Examples 1-18. The characterization of the pore structure is given in Example 19.

[0085] The synthesis procedure consists of (1) preparation of the aqueous phase, (2) preparation of the organic phase, (3) suspension polymerization, (4) purification of the resulting porous polymer sorbent product (work-up), and (5) Add blood compatibility coating.

[0086] The following synthesis method was generally applicable to all samples made. The synthesis procedure differed between each polymer sample; referring to Table 6, the following is a general procedure in order to view the specific operating conditions for each example.

[0087] Reactor setup. An over-head stirrer, water-cooled condenser, multi-stage stirrer blades, thermocouple and bubbler were installed in a 5L or 0.5L tank reactor. For a 0.5L kettle, install a gasket between the top cover and the bottom ...

Embodiment 19

[0099] Example 19: Pore Structure Characterization

[0100] Use Micromeritics Autopore IV9500V1.09 mercury penetration meter (mercury intrusion meter) or Micromeritics ASAP 2010 meter (N 2 desorption) to analyze the pore structure of the adsorbent polymer. The results are shown in figure 1 , where the pore volume is plotted as a function of pore diameter. figure 1 is the logarithmic differential pore structure used in Examples 1-18.

Embodiment 20

[0101] Example 20: Pore Structure Features

[0102] The pore volumes of the various sorbent polymers are divided into categories within the pore size range and these values ​​are provided in Tables 7 and 8. In the first range, the capacity pore volume (capacity pore volume) is the volume of such pores that can accept protein adsorption and have a diameter larger than The pore volume composition of the pores. An effective pore volume is a pore volume that selectively accepts proteins of less than about 50,000 Daltons and that ranges in diameter from 100 to range of hole diameters. Oversized pore volumes are acceptable for proteins greater than about 50,000 Daltons and consist of diameters greater than The pore volume composition of the pores. Undersized pore volumes are those with diameters smaller than And pore volumes for proteins greater than about 10,000 Daltons are not acceptable.

[0103] In the second range, the capacitive pore volume is the pore volume that ca...

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Abstract

Provided herein are materials and methods of reducing contamination in a biological substance or treating contamination in a subject by one or more toxins comprising contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxin, wherein the sorbent comprises a plurality of pores ranging from 50Å to 40,000Å with a pore volume of 0.5 cc / g to 5.0 cc / g and a size of 0.05 mm to 2 cm and sorbing the toxin. Also provided are kits to reduce contamination by one or more toxins in a biological substance comprising a sorbent capable of sorbing a toxin, wherein the sorbent comprises a plurality of pores ranging from 50Å to 40,000Å with a pore volume of 0.5 cc / g to 5.0 cc / g and a size of 0.05 mm to 2 cm and a vessel to store said sorbent when not in use together with packaging for same.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application No. 61 / 666,626, filed June 29, 2012, which is hereby incorporated by reference in its entirety. technical field [0003] The present invention generally relates to materials, methods, kits and devices for reducing toxin contamination. Background technique [0004] Toxins are exogenous or endogenous substances that disrupt normal physiological functions and may cause disease. They cause disease by coming into contact with or being absorbed by body tissues, including the intestines, skin or mucous membranes. There are thousands, if not millions, of substances that can act as toxins. Even some substances that are not normally toxins can become toxins under the right conditions. Toxins vary significantly in their strength and speed of action. Treatments for toxin exposure have been developed, including removal of exposure to the toxin and use of antidote...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/34C09K23/38C09K23/48C09K23/52
CPCA61M1/3679B01J20/28078B01J20/28069B01J20/261A61P1/00A61P1/04A61P29/00A61P31/04A61P37/06A61P39/02A61P7/10A61K9/16A61M2202/0057A61M2202/0413A61M2202/0415A61M2202/0405A61M2202/0464A61M2202/0466A61M2202/0492A61M2202/0496A61M2202/049A61M2202/20A61M2202/203A61M2202/206A61K31/765A61M2202/0423C08F299/00C08J9/26C08J2201/0444C08J2207/10C08J2353/00
Inventor 菲利普·P·哈恩文森特·J·卡波尼托马斯·D·戈洛比什胡迈拉·贝居姆·阿利
Owner CYTOSORBENTS CORP
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