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Medicine for treating orthopedic disease, preparation method, test method and application of medicine

A technology of drugs and medicinal materials, which is applied in the field of pharmaceutical compositions for the treatment of femoral head necrosis, and can solve problems such as incomplete understanding of pathophysiological mechanisms

Inactive Publication Date: 2015-04-29
袁福德
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Recent studies have found that in patients with avascular necrosis of the femoral head, the activity and number of bone marrow mesenchymal stem cells are inhibited, suggesting that avascular necrosis of the femoral head may be a disease of bone cells and mesenchymal stem cells, but its exact pathophysiology The mechanism is still not fully understood

Method used

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  • Medicine for treating orthopedic disease, preparation method, test method and application of medicine
  • Medicine for treating orthopedic disease, preparation method, test method and application of medicine
  • Medicine for treating orthopedic disease, preparation method, test method and application of medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0207] Prescription: bitter eggplant 600g, pine wormwood 200g, soft water coptis 200g.

[0208] Preparation method: Take 600g of dried bitter eggplant, 200g of pine wormwood, and 200g of soft water Coptis chinensis, mix them, and add 10000mL of water to the medicinal materials for microwave extraction 3 times, each time for 30min, combine the extracts, concentrate, dry, grind into fine powder, add auxiliary materials (starch ), mix well, pack into capsules, and make 1000 hard capsules.

[0209] Detection method:

[0210] (1) Chromatographic conditions: Chromatographic column: C18 column (200mm×4.6mm, 5μm), mobile phase: methanol-1% glacial acetic acid (10:90), flow rate: 1.0mL / min, detection wavelength: 280nm. The number of theoretical plates should not be less than 2500 based on the kaempferol peak.

[0211] (2) Solution preparation:

[0212] ①The solution of the test product: take 10g of the drug of the present invention, grind it finely, take about 0.8g, accurately weigh...

Embodiment 2

[0217] Prescription: bitter eggplant 166g, pine wormwood 332g, soft water coptis 498g.

[0218] Preparation method: Take 166g of dried bitter eggplant, 332g of pine wormwood, and 498g of soft water Coptis chinensis, mix them, and add 10000mL of water to the medicinal materials for microwave extraction 3 times, 30min each time, combine the extracts, concentrate, dry, grind into fine powder, add auxiliary materials (starch ), mixed evenly, compressed into tablets, coated, and made into 1000 tablets.

[0219] Detection method:

[0220] (1) Chromatographic conditions: Chromatographic column: C18 column (200mm×4.6mm, 5μm), mobile phase: methanol-1% glacial acetic acid (10:90), flow rate: 1.0mL / min, detection wavelength: 280nm. The number of theoretical plates should not be less than 2500 based on the kaempferol peak.

[0221] (2) Solution preparation:

[0222] ①The solution of the test product: take 10g of the drug of the present invention, grind it finely, take about 0.8g, accu...

Embodiment 3

[0227] Prescription: bitter eggplant 286g, pine wormwood 429g, soft water coptis 286g.

[0228] Preparation method: Take 286g of dried bitter eggplant, 429g of pine wormwood, and 286g of soft water Coptis chinensis, mix them, and add 10000mL of water to the medicinal materials for microwave extraction 3 times, each time for 30min, the extracts are combined, concentrated, dried, crushed into fine powder, and added with auxiliary materials (starch ), mixed, dried, and made into 5000 pills.

[0229] Detection method:

[0230] (1) Chromatographic conditions: Chromatographic column: C18 column (200mm×4.6mm, 5μm), mobile phase: methanol-1% glacial acetic acid (10:90), flow rate: 1.0mL / min, detection wavelength: 280nm. The number of theoretical plates should not be less than 2500 based on the kaempferol peak.

[0231] (2) Solution preparation:

[0232] ①The solution of the test product: take 10g of the drug of the present invention, grind it finely, take about 0.8g, accurately wei...

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Abstract

The invention belongs to the field of traditional Chinese medicine and particularly relates to a medicine composition for treating femoral head necrosis. The invention discloses a medicine for treating an orthopedic disease, and a preparation method, a test method and an application of the medicine. The medicine composition is prepared by taking and mixing the following raw materials in parts by weight: bitter nightshade, phtheirospermum japonicum and herb of manybranch meadowrue, adding 5-15 times of water into the medicinal materials for microwave extraction for 1-5 times, 15-60min each time, merging extracts, condensing, drying, grinding into fine powder, adding an auxiliary material, mixing and preparing into a granule. The medicine composition can be used for preparing a medicine for treating the femoral head necrosis. The invention further provides the test method of the medicine composition.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a medicinal composition for treating necrosis of the femoral head, which is composed of bitter eggplant, pine wormwood and soft water coptis. technical background: [0002] Avascular necrosis of the femoral head (ONFH) is caused by the destruction of the blood supply of the femoral head due to different etiologies, which leads to subchondral bone degeneration and necrosis, and then causes the femoral head to collapse, eventually leading to degenerative and destructive changes of the hip joint. The disease mostly occurs in young adults aged 35 to 55. If it is not treated in time, 70% of the patients will have a collapsed femoral head, and total hip replacement will be required in about 3 to 4 years. It is generally believed that the intake of hormones and alcohol are the two most common causes of avascular necrosis of the femoral head, accounting for about 40% of the ...

Claims

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Application Information

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IPC IPC(8): A61K36/81A61P19/08A61P19/02G01N30/02
Inventor 袁福德
Owner 袁福德
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