Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of sodium butyrate in preparation of medicine for preventing noise-induced hearing loss

A technology for hearing loss and sodium butyrate, applied in drug combination, active ingredients of anhydride/acid/halide, food science, etc., can solve the problems of no sodium butyrate, prevention of noise-induced deafness without sodium butyrate, etc. Achieve the effects of reducing evoked potential threshold shift, good research and application prospects, and preventing noise-induced deafness and cannon-shock deafness

Active Publication Date: 2016-10-26
FOURTH MILITARY MEDICAL UNIVERSITY
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, there has been no report on the activity of sodium butyrate in preventing noise-induced hearing loss, nor has there been any report on the prevention of noise-induced deafness by sodium butyrate

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of sodium butyrate in preparation of medicine for preventing noise-induced hearing loss

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0028] The present invention provides a new application of sodium butyrate (its structural formula is shown in formula (1)), i.e. the application of sodium butyrate in the prevention of noise-induced hearing loss, wherein said noise-induced hearing loss includes noise-induced deafness and cannon-shock deafness.

[0029]

[0030] The sodium butyrate described in the present invention is purchased from the market and purchased from the American Chemical Abstracts Service (CAS) with an identification code of CAS NO.: 156-54-7.

[0031] The sodium butyrate of the present invention can be mixed with pharmaceutically acceptable auxiliary materials when preventing noise-induced hearing loss, and prepared into any pharmaceutical preparation suitable for clinical use according to the conventional pharmaceutical preparation process, such as capsules, Tablets, pills, granules, oral liquid preparations, etc.

[0032] Wherein the pharmaceutically acceptable auxiliary materials include ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an application of sodium butyrate for preventing noise-induced hearing loss, and belongs to the technical field of biological medicine. According to the application of sodium butyrate for preventing noise-induced hearing loss, in the noise-induced hearing loss experiment of mice models, sodium butyrate can reduce the auditory brainstem response threshold shift after noise exposure, increase the survival rate of cochlear hair cells after noise exposure, has excellent noise-induced hearing loss preventing effect on noises at multiple frequencies, especially has excellent preventative effect on noise-induced hearing loss, explosive hearing loss and other diseases, can be used for preparing drugs and / or healthcare products for preventing noise-induced hearing loss, has good research and application prospects, and can fill in the gap of drugs for preventing noise-induced hearing loss at present.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to a new application of sodium butyrate, in particular to the application of sodium butyrate in preventing noise-induced hearing loss. Background technique [0002] Noise-induced hearing loss refers to progressive sensorineural deafness caused by prolonged exposure to high-intensity noise environments. Noise-induced deafness is a cumulative disease that generally goes through four stages: auditory adaptation, hearing fatigue, early noise-induced deafness, and noise-induced deafness. The early clinical manifestations are an increase in the 4KHz hearing threshold. If it continues to develop, high-frequency hearing loss will occur, and gradually develop to the low-frequency band, and there will be general hearing loss from 500Hz to 8KHz, accompanied by persistent high-pitched tinnitus. [0003] There are two ways to prevent noise-induced deafness, one is to avoid noise exposure, and ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/19A61P27/16A23L33/10
CPCA61K31/19
Inventor 陈福权邱建华王洁温立婷米文娟
Owner FOURTH MILITARY MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com