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Pharmaceutical composition containing cucurbitacine and preparation method thereof

A composition and cucurbitacin technology are applied in the field of medicinal preparations in the field of medicine, and can solve the problems of efficacy change, toxicity, inability to compare the stability of cucurbitacin unilateral preparations, etc.

Active Publication Date: 2015-04-29
DELI WEI BEIJING BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although vitamin E has many benefits to the human body, it must not be taken casually
Scientific research results have shown that the abuse of vitamin E is not only useless to the body, but also may be harmful, and long-term high-dose application will have potential toxicity
In addition, "a stable liquid preparation of cucurbitacin and its production method" uses Brucea javanica oil as an oil solvent. As we all know, Brucea javanica oil itself is an anticancer drug. Therefore, this patent application actually discloses a compound The preparation, its efficacy, etc. have all changed, and the stability cannot be directly compared with the cucurbitacin single preparation

Method used

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  • Pharmaceutical composition containing cucurbitacine and preparation method thereof
  • Pharmaceutical composition containing cucurbitacine and preparation method thereof
  • Pharmaceutical composition containing cucurbitacine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] 1000 preparation dose prescription:

[0067] Cucurbitacin (cucurbitacin B content not less than 60%) 0.1g

[0068] Medium Chain Triglycerides 100g

[0069] Ascorbyl Palmitate 0.005g

[0070] Preparation method: weigh cucurbitacin and ascorbyl palmitate, put them in a 500ml beaker, add medium-chain triglycerides, heat in a water bath at 60°C, stir until cucurbitacin and ascorbyl palmitate are completely dissolved and mixed evenly to obtain .

Embodiment 2

[0072] 1000 preparation dose prescription:

[0073] Cucurbitacin (cucurbitacin B content not less than 70%) 0.1g

[0074] soybean oil 100g

[0075] Ascorbyl Palmitate 0.005g

[0076] Preparation method: with embodiment 1.

Embodiment 3

[0078] 1000 preparation dose prescription:

[0079] Cucurbitacin (cucurbitacin B content not less than 80%) 0.1g

[0080] olive oil 100g

[0081] Ascorbyl Palmitate 0.005g

[0082] Preparation method: with embodiment 1.

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Abstract

The invention provides a steady composition containing cucurbitacine. The composition provided by the invention contains cucurbitacine, an oil solvent and a stabilizing agent, wherein the stabilizing agent is ascorbyl palmitate or a mixture of ascorbyl palmitate and vitamin E. The composition provided by the invention has high bioavailability; and in addition, the stability of cucurbitacine preparations can be obviously increased.

Description

technical field [0001] The invention relates to medicinal preparations in the field of medicine, in particular to a medicinal composition containing cucurbitacin and a preparation method thereof. Background technique [0002] Cucurbitacins is a general term for a mixture of cucurbitacins. It is a class of highly oxidized tetracyclic triterpenoids extracted from plants. More than 40 types have been found so far. The basic skeleton structure of this type of compound is: [0003] [0004] Cucurbitacin B (CuB): R1-OH, R2-=O, R3-H, R4-Ac, Δ23, 24; [0005] Isocucurbitacin B (isoCuB): R1-=O, R2-OH, R3-H, R4-Ac, Δ23, 24; [0006] Cucurbitacin D (CuD): R1-OH, R2-=O, R3-H, R4-H, Δ23, 24; [0007] Cucurbitacin E (CuE): R1-OH, R2-=O, R3-H, R4-Ac, Δ1,2, Δ23,24; [0008] Cucurbitacin I (CuI): R1-OH, R2-=O, R3-H, R4-H, Δ1,2, Δ23,24. [0009] The difference between them lies in the hydroxylation of C2, C3, C19, and C24, the carbonyl of C3, the double bond between C1~C2, the double b...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K9/02A61K9/48A61K31/575A61K47/44A61K47/28A61P1/16A61P35/00
Inventor 邓吉林吴莹程晓波吴宝珍邓红玲
Owner DELI WEI BEIJING BIOLOGICAL TECH
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