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Flupirtine maleate sustained release tablet and preparation method thereof

A technology of flupirtine acid sustained-release tablets and flupirtine maleate, which is applied in the fields of pharmaceutical formulations, muscular system diseases, neuromuscular system diseases, etc., can solve the problems of poor capsule stability and absorption, and achieve Stable therapeutic effect, simple preparation method, good drug stability

Inactive Publication Date: 2015-04-22
HARBIN SHENGJI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The drug currently on the market is flupirtine maleate capsules, but the stability and absorbability of the capsules are not very good. Therefore, there is an urgent need for a drug on the market A kind of flupirtine maleate sustained-release tablet and preparation method thereof

Method used

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  • Flupirtine maleate sustained release tablet and preparation method thereof

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Effect test

Embodiment 1

[0024] A flupirtine maleate sustained-release tablet and a preparation method thereof, which are made of flupirtine maleate, a sustained-release framework material, and a lubricant, wherein, in parts by weight, 0.2 parts of flupirtine maleate, 70-190 parts of slow-release matrix material, 10-20 parts of lubricant.

[0025] According to the optimal parts by weight, 0.2 parts of flupirtine maleate, 70 parts of sustained-release matrix material and 15 parts of lubricant.

[0026] The sustained-release matrix material is hypromellose.

[0027] The hypromellose is one of 75hd100cr hypromellose, 75hd4000cr hypromellose, 75hd15000cr hypromellose, 100000cr hypromellose or a mixture of both.

[0028] Described lubricant is magnesium stearate, talcum powder, silicon dioxide or a mixture of both.

Embodiment 2

[0030] A flupirtine maleate sustained-release tablet and a preparation method thereof, the specific steps of the preparation method are:

[0031] Step 1, material preparation: pulverize flupirtine maleate with a pulverizer, pass through a 100-mesh sieve, and set aside;

[0032] Step 2: Total mixing: weigh flupirtine maleate and hypromellose in parts by weight, put them in a three-dimensional mixer and mix for 30 minutes, take them out for later use;

[0033] Step 3: Granulation: Put the mixed fine powder of raw and auxiliary materials into the wet granulator, use pure water as the binder, put the binder into the liquid supply tank, turn on the machine, adjust the parameters, and start adding the moistening Wet agent, open the shear flying knife at the same time, 2-5 minutes, discharge, use a swing granulator, granulate with a 18-mesh nylon screen, use a fluidized bed dryer to dry, first dry with cool wind, wait After the skin is completely dry, turn on the hot air heating, th...

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Abstract

The invention discloses a flupirtine maleate sustained release tablet. The flupirtine maleate sustained release tablet is prepared from, by weight, 0.2 parts of flupirtine maleate, 70 to 190 parts of a sustained-release matrix material, and 10 to 20 parts of a lubricant. A preparation method of the flupirtine maleate sustained release tablet comprises following steps: material preparation, total blending, granulating, total blending, performing, and aluminum plastic packaging. The flupirtine maleate sustained release tablet is capable of relieving pain, relaxing muscle, and protecting nerve. According to the preparation method, novel sustained release preparations are adopted. According to the sustained release preparations, medicine releasing rate of medicines from the preparations is slowed, and absorption rate of the medicines in body is reduced, so that more stable treatment effects are achieved. Compared with oral liquid, the flupirtine maleate sustained release tablet is high in drug stability, and is convenient for packaging, transportation, and storing; and the preparation method is simple and convenient, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of chemical drug sustained-release preparations, and in particular relates to a flupirtine maleate sustained-release tablet and a preparation method thereof. Background technique [0002] Flupirtine maleate is a new type of analgesic, and its mechanism of action is a selective neuronal potassium channel opener (Selective Neuronal Potassium Channel Opener, SNEPCO), which has triple effects of analgesia, muscle relaxation and neuroprotection. It is mainly used for the treatment of various types of moderate acute pain, such as pain caused by surgery, trauma, etc., as well as headache, migraine and abdominal cramps. [0003] The medicine existing on the market is flupirtine maleate capsules, but the stability and absorbability of the capsules are not very good, therefore, a kind of flupirtine maleate slow-release tablet and its preparation method are urgently needed on the market. Contents of the invention [0004] The...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/44A61P29/00A61P21/02A61P25/00A61P25/06
Inventor 马玉国
Owner HARBIN SHENGJI PHARMA
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