A kind of synthetic method of water-soluble porphyrin and its photocatalytic application

Abstract

The invention discloses a synthesis method for water-soluble porphyrin. The chemical compound is named as tetraiodide 5,10,15,20-tetra{4-[2-(N,N-dimethyl-2-piperidine) ethyoxyl]phenyl}porphyrin. The synthesis method comprises the following steps: 1) synthesizing 5,10,15,20-tetra(4-hydroxy phenyl) porphyrin; 2) synthesizing 5,10,15,20-tetra{4-[2-(N-methyl-2-piperidine) ethyoxyl] phenyl}porphyrin; 3) synthesizing the water-soluble porphyrin target object. The prepared water-soluble porphyrin is used for studying the influences of porphyrin in different concentrations on cutting pBR322 plasmid DNA under the acidity and neutrality conditions, as well as the lighting and dark conditions, through the photocatalytic DNA cutting experiments. The synthesis method has the advantages of being simple and easy in synthesis process and relatively high in product purity; chemicals used in the whole process are less in toxicity; the product is good in water solubility, and has good pH selectivity.

Description

technical field [0001] The patent of the present invention relates to the field of organic synthesis and chemical analysis, especially a synthesis method of water-soluble porphyrin and its photocatalytic application. Background technique [0002] Porphine is a kind of macromolecular heterocyclic compound formed by interconnecting α-carbon atoms of four pyrrole subunits through methine bridges (=CH-), and porphines with substituents are called porphyrins. The carbons (5, 10, 15, 20) between the four pyrrole rings are called the middle carbon, and the remaining 8 carbons that can be substituted are called the outer ring carbons. Different substituents can be connected to the middle carbon to form a series of porphyrins. Porphyrin compounds are aromatic and have two resonance isomers. There are 26 π electrons in the ring. It is a highly conjugated system and is generally a dark solid with a high melting point. [0003] Because of their unique structures and properties, porphy...

AI Technical Summary

Problems solved by technology

First of all, the solubility of porphyrin compounds is poor, and it is inevitable to introduce some harmful solvents when acting on organisms; secondly, the residence time in the body is long, the selectivity is poor, and they are retained in the tissue, and have certain toxic side effects on healthy cells; in addition, Photobleaching of photodynamic therapeutic agents also occurs in porphyrins

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