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Iron-based montmorillonite imaging contrast agent and preparation method thereof

A technology of iron-based montmorillonite and contrast agent, which is applied in the direction of MRI/MRI contrast agent, etc., can solve the problems of high price and difficult to unify product standards.

Inactive Publication Date: 2015-04-08
SHANDONG SBOND PHARMA
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  • Application Information

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Problems solved by technology

[0007] At present, nano-biological materials are widely used in clinical practice. Among them, uhrasmall superparamagnetic iron oxide USPIO is a new type of negative contrast agent for MRI examination. It is expensive and the standards of related products are difficult to unify. Therefore, the study of MRI contrast agents is in the ascendant

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  • Iron-based montmorillonite imaging contrast agent and preparation method thereof
  • Iron-based montmorillonite imaging contrast agent and preparation method thereof
  • Iron-based montmorillonite imaging contrast agent and preparation method thereof

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Embodiment Construction

[0011] The technical scheme of the present invention is as follows:

[0012] An iron-based montmorillonite imaging contrast agent, comprising active ingredients of a medicine and pharmaceutical excipients; the active ingredient of the medicine is iron-based montmorillonite, and the dosage percentage is 50-100 wt%; the pharmaceutical excipients are excipients And / or flavoring agent, the dosage percentage is 0-50wt%; the weight percentage of iron ions in the iron-based montmorillonite is 9.0-12.0%.

[0013] The iron-based montmorillonite is obtained by dissolving an Fe source in an acid solution and performing ion exchange with medicinal montmorillonite under the protection of nitrogen; wherein the acid solution is 5N hydrochloric acid, 5-30 %W / w sulfuric acid or 5-30%w / w citric acid solution, the Fe source is Fe 3 O 4 Or Fe 2 O 3 The medicinal montmorillonite is selected from calcium-based montmorillonite, sodium-based montmorillonite or magnesium-based montmorillonite, and the medi...

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Abstract

The invention discloses an iron-based montmorillonite imaging contrast agent and a preparation method thereof. The contrast agent is prepared from a medical active ingredient and pharmaceutic adjuvants, wherein the medical active ingredient, namely iron-based montmorillonite accounts for 50-100wt%; the pharmaceutic adjuvants, namely an excipient and / or a corrigent account(s) for 0-50wt%; the weight percentage of iron ions in the iron-based montmorillonite is 9.0-12.0%. The prepared iron-based montmorillonite (Fe-montmorillonite) particles are capable of adjusting the molar ratio of Fe and optimizing the bimodal imaging effect, and also can be suspended and dispersed in a water-based solution for a long time; the iron-based montmorillonite particles have excellent biocompatibility and targeting imaging effect and can be applied to MRI / CT bimodal imaging targeting diagnosis.

Description

Technical field [0001] The invention relates to an iron-based montmorillonite imaging contrast agent and a preparation method thereof. The invention belongs to the technical field of medical imaging contrast agent medicine. Background technique [0002] In recent years, with the development of magnetic resonance imaging contrast agents, people have received extensive attention and great research interest in this emerging field. The early diagnosis and treatment of tumors is an important research topic in the world today. The application of science and technology to develop high-accuracy early diagnosis of tumor molecular imaging imaging technology usually requires appropriate contrast agents to assist early diagnosis of tumors. In order to achieve the effect of contrasting tissues in the body, contrast agents are usually composed of inorganic compounds, metals or oxides. [0003] At present, X-ray contrast agent (barium sulfate) is commonly used in the digestive tract, which is div...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/08
Inventor 乔敏
Owner SHANDONG SBOND PHARMA
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