Pressure-coupled chromatography column fluid distributor

Abstract

A pressure coupling type chromatographic column fluid distributor. The fluid distributor comprises a first distribution plate (20) and a second distribution plate (30). The first distribution plate (20) and the second distribution plate (30) are respectively disposed on two ends of a separation purpose gel (40) in a chromatographic column (10). Multiple radial first fluid grooves (21) are distributed in a spaced manner along the circumference of a side surface, opposite to the gel (40), of the first distribution plate (20). A first screen mesh (51) is disposed on the outer side of the corresponding first fluid groove (21). A fluid outlet / inlet (22) in communication with the corresponding first fluid groove (21) is disposed at the center of the first distribution plate (20). Multiple radial second fluid grooves (31) are distributed in a spaced manner along the circumference of a side surface, opposite to the gel (40), of the second distribution plate (30). A second screen mesh (52) is disposed on the outer side of the corresponding second fluid groove (31). An annular flow groove (32) is formed between the edge of the second distribution plate (30) and the tail end of the corresponding second fluid groove (31). A fluid inlet / outlet (33) is disposed at the center of the second distribution plate. Multiple radial flow channels (34) for connecting the annular flow grooves (32) and the fluid inlet / outlet (33) are evenly distributed in the side surface, opposite to the gel, of the second distribution plate.

Description

【Technical field】 [0001] The invention relates to a chromatographic column in gel chromatography technology, in particular to a pressure-coupled chromatographic column fluid distributor. 【Background technique】 [0002] Chromatography is a gel separation method, typically silica gel chromatography. It is separated by reacting the separation fluid with the gel in the chromatographic column through molecular sieve, ion exchange, etc. Chromatographic column is the main body of gel chromatography technology, generally using glass tube or plexiglass tube, which is filled with gel, and equipped with fluid distribution plate and sieve plate at both ends. Such as Figure 8 As shown, the traditional chromatographic column fluid distribution plate has a radial flow groove on one side, and a liquid inlet or outlet in the center. The fluid enters from the liquid inlet, flows through the radial flow groove to the edge of the fluid distribution plate, and then The gel flows out to the ed...

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Problems solved by technology

like Figure 8 As shown, the traditional chromatographic column fluid distribution plate has a radial flow groove on one side, and a liquid inlet or outlet in the center. The fluid enters from the liquid inlet, flows through the radial flow groove to the edge of the fluid distribution plate, and then The gel flows out to the edge of another fluid distribution plate, and then flows through the flow channel of another fluid distribution plate to its central liquid outlet, or directly flows through the gel to another fluid from the central liquid inlet of a fluid distribution plate The liquid outlet in the center of the distribution plate flows out, causing the fluid to pass through different paths from the liquid inlet to the liquid outlet. The flow rate of the fluid per unit area of ​​the gel is quite different, which makes the flow distribution of the fluid in the gel uneven, thus affecting the chromatography efficiency

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