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Application of vitamin K3 in preparation of drug for treating bacterial infection

A bacterial infection and vitamin technology, applied in the direction of antibacterial drugs, anhydride/acid/halide active ingredients, etc., can solve the problems such as no vitamin K antibacterial, no anti multidrug resistance bacteria and so on.

Inactive Publication Date: 2015-03-18
JIANGXI AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But nothing about vitamin K 3 There are no reports of anti-bacteria, let alone anti-multi-drug-resistant bacteria

Method used

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  • Application of vitamin K3 in preparation of drug for treating bacterial infection
  • Application of vitamin K3 in preparation of drug for treating bacterial infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Vitamin K 3 antimicrobial and anti-multidrug-resistant bacteria test

[0013] 1. Experimental materials and methods

[0014] Test strain:

[0015] Staphylococcus aureus: Staphylococcus aureus ATCC 25923, S. aureus S014; Bacillus subtilis: Bacillus subtilis S028.

[0016] Methicillin-resistant Staphylococcus aureus standard strain: Methicillin-resistant S. aureus ATCC 33592 (MRSA ATCC 33592); Methicillin-resistant Staphylococcus aureus clinical strains: MRSA 01, MRSA 02 and MRSA 03.

[0017] MHB medium: 2.0 g beef extract powder, 1.5 g soluble starch, 17.5 g acid hydrolyzed casein, 1000 mL pure water, pH 7.4.

[0018] Preparation of test sample solution: Weigh each accurately 1 with 2 Appropriate amount, add a small amount of DMSO to dissolve, and then use MHB medium to prepare a test sample solution with a final concentration of 256 μg / mL (DMSO concentration is less than 5%).

[0019] According to the CLSI standard, the antibacterial and anti-multidrug...

Embodiment 2

[0027] Vitamin K 3 Tablet preparation

[0028] 1. Prescription Dosage per tablet 300 tablets

[0029] Vitamin K 3 (2-methyl-1,4-naphthoquinone, 1 ) 0.0750g 22.5g

[0030] Starch 0.0200g 6g

[0031] 10% starch slurry appropriate amount

[0032] Magnesium stearate appropriate amount;

[0033] 2. Preparation method:

[0034] (1) Preparation of 10% starch slurry: Add 2g of starch into about 20ml of purified water, heat and gelatinize to make 10% starch slurry.

[0035] (2) Granulation: Take the prescribed amount of 2-methyl-1,4-naphthoquinone ( 1 ) mixed with starch evenly, add an appropriate amount of 10% starch slurry to make soft material, granulate through a 16-mesh sieve, dry the wet granules at 40-50°C, granulate with a 16-mesh sieve and mix with magnesium stearate.

[0036] (3) Tablet compression: the above vitamin K 3 The granules are compressed on a tablet machine to obtain vitamin K 3 Tablets.

[0037] (4) Coating: vitamin K 3 Vegetarian tablets coated wi...

Embodiment 3

[0043] Vitamin K 3 Preparation of Injection

[0044]1. Prescription 500 sticks per stick

[0045] Vitamin K 3 (sodium bisulfite menadione, 2 ) 0.0200g 10.0g

[0046] Sodium bisulfite 0.0005g 0.25g

[0047] Add water for injection to 1000mL;

[0048] 2. Preparation method:

[0049] (1) Preparation of injection: Measure 80% of the prescribed amount of water for injection, saturate it with carbon dioxide, and add the prescribed amount of menadione sodium bisulfite ( 2 ) to make it dissolve, slowly add sodium bicarbonate step by step, stir to dissolve completely, then adjust the pH of the liquid to 2.5~3.5, and add water for injection saturated with carbon dioxide to a sufficient amount. with G 3 The vertical melting funnel pre-filtered, and then finely filtered with a 0.45 μm microporous membrane. Check filtrate clarity.

[0050] (2) Filling and fusion sealing: Immediately fill the filtered medicinal liquid into a 2 mL ampoule, and pass carbon dioxide into the upper s...

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Abstract

The invention discloses an application of vitamin K3 in preparation of drug for treating bacterial and multiple resistant bacterial infection. By means of a CLSI standard method, research to anti-bacterial activity and anti-multiple-resistant-bacterial activity of the vitamin K3 is carried out with a result proving that: the vitamin K3 has significant inhibiting effect on growth of all test bacterial strains, which means that the vitamin K3 is significant in anti-bacterial activity and anti-multiple-resistant-bacterial activity and shows that the vitamin K3 is excellent in application and development prospect. The vitamin K3 can be used for preparing the drug for treating the bacterial and multiple resistant bacterial infection.

Description

technical field [0001] The present invention relates to vitamin K 3 The application in the preparation of medicines for treating bacterial infections, especially the application in the preparation of medicines for treating multidrug-resistant bacterial infections. Background technique [0002] In recent years, multidrug-resistant bacterial infections have spread all over the world, and the infection rate has continued to rise, and resistance to clinical antibiotics of various structural types has emerged one after another. bacteria, a serious threat to human life and health. In view of many reasons such as the low success rate of antibiotic research and development and uncertain prospects, only 5 of the 15 large global pharmaceutical companies involved in this field are still persisting in the research and development of antibiotics, resulting in a serious lag in the launch of new antibiotics, and the research and development of new antibacterial drugs seems to be a problem...

Claims

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Application Information

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IPC IPC(8): A61K31/122A61K31/185A61P31/04
CPCA61K31/122A61K31/185
Inventor 袁干军苏秋玲朱潇逸曹金龙
Owner JIANGXI AGRICULTURAL UNIVERSITY
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