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Application of Cape jasmine extractive from active components of Qingkailing for preparing multiple-resistant bacteria resistant medicine

A technology of gardenia extract and multi-drug resistant bacteria is applied in the directions of antibacterial drugs, resistance to vector-borne diseases, and medical preparations containing active ingredients, which can solve the problem of few options for antibacterial drugs.

Active Publication Date: 2013-03-27
SHINEWAY PHARMA GRP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, multidrug-resistant bacterial infections are showing an increasing trend, but there are few antimicrobial drug options, so heavily drug-resistant bacterial infections have become a global problem

Method used

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  • Application of Cape jasmine extractive from active components of Qingkailing for preparing multiple-resistant bacteria resistant medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation method of gardenia extract

[0026] (1) Take an appropriate amount of gardenia, add water to decoct twice, add 8 times the amount of water for the first time, boil for 2 hours, add 6 times the amount of water for the second time, boil for 1 hour, filter, and combine the two filtrates; ( 2) Concentrate the obtained filtrate under reduced pressure to 1.5-2 times the volume of the original medicinal material, let it cool, add ethanol under stirring to make the alcohol content reach 60%, refrigerate, filter, recover ethanol from the filtrate, add water to dilute to a relative density of 1.05- 1.2 (60°C), filter; (3) Put the obtained filtrate on the macroporous adsorption resin, and then elute with 5 to 7 times the column volume of water and 8 to 10 times the column volume of 40% ethanol, and collect the eluate , filtered, and the ethanol was recovered under reduced pressure until there was no alcohol smell, and the gardenia extract was obtained, which was re...

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Abstract

The invention relates to a Cape jasmine extractive from active components of Qingkailing, which has inbibitional effects on Acinetobacter calcoaceticus, Acinetobacter baumannii, A.baumannii, Stenotrophomonasmaltophilia and Escherichia coli containing NDM-1 drug resistant genes, therefore, the Cape jasmine extractive can be used for inhibiting the bacterial diseases and curing and / or preventing diseases caused by bacteria.

Description

technical field [0001] The invention relates to a new medical application of gardenia jasminoides, in particular to the application of gardenia jasmine extracts in the preparation of anti-multi-drug-resistant bacteria drugs. Background technique [0002] Multiple resistant bacteria refer to pathogenic bacteria with multiple drug resistance, that is, one microorganism is resistant to three types of antibiotics (such as aminoglycosides, erythromycin, and B-lactams) or more than three types of antibiotics at the same time. The most common ones are NDM-1, MDR-TB, MDR-MRSA, and Acinetobacter baumannii and Pseudomonas aeruginosa that often appear in ICU. NDM-1 (NewDelhimetallo-β-lactamase-1, New Delhi Metallo-β-lactamase), also known as NDM-1 bacteria, is a carbapenem-resistant enzyme. The NDM-1 gene is often carried by a plasmid, but it is also integrated on the bacterial chromosome, which is easy to spread and spread among different strains. The molecular weight of the protein ...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P31/04
CPCY02A50/30
Inventor 刘军锋袁静张状年黄留玉李东王雪松姜海
Owner SHINEWAY PHARMA GRP LTD
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