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Olmesartan medoxomil tablet and preparation method thereof

A kind of technology of olmesartan medoxomil and tablet core, applied in the field of olmesartan medoxomil tablet and preparation

Active Publication Date: 2015-03-11
哈药集团股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention is proposed for the problem that there is no clinically usable powder direct compression olmesartan medoxomil tablet in the prior art, for this reason, the main purpose of the present invention is to provide a kind of preparation method of powder direct compression olmesartan medoxomil tablet, to solve the above problems

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preparation of embodiment 1 olmesartan medoxomil tablet

[0037] The weight of each component of the tablet core of every 1000 olmesartan medoxomil tablets consists of: olmesartan medoxomil 20g, lactose 100g, microcrystalline cellulose 39g, low-substituted hydroxypropyl cellulose 30g, polylactic acid 10g, magnesium stearate 1g; the above components are compressed into tablets and coated with film coating, and the film coating solution is prepared from the following materials: 20g of Opadry, 5g of polylactic acid dissolved in 200g of 80% ethanol, and mixed uniformly.

Embodiment 2

[0038] The preparation of embodiment 2 olmesartan medoxomil tablets

[0039] The weight of each component of the tablet core of every 1000 olmesartan medoxomil tablets consists of: olmesartan medoxomil 18g, lactose 80g, microcrystalline cellulose 30g, low-substituted hydroxypropyl cellulose 30g, polylactic acid 8g, magnesium stearate 0.5g; the above components are compressed into tablets and coated with film coating, and the film coating solution is prepared from the following materials: 20g of Opadry, 5g of polylactic acid dissolved in 200g of 80% ethanol, and mixed uniformly to obtain.

Embodiment 3

[0040] The preparation of embodiment 3 olmesartan medoxomil tablets

[0041] The weight of each component of the tablet core of every 1000 olmesartan medoxomil tablets consists of: olmesartan medoxomil 22g, lactose 120g, microcrystalline cellulose 45g, low-substituted hydroxypropyl cellulose 50g, polylactic acid 12g, magnesium stearate 1.5 g; the above components are compressed into tablets and coated with a film coating, and the film coating solution is prepared from the following materials: 20 g of Opadry, 5 g of polylactic acid dissolved in 200 g of 80% ethanol, and mixed uniformly.

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Abstract

The invention relates to the field of medicines, and particularly relates to an olmesartan medoxomil tablet and a preparation method thereof. Tablet cores of every 1,000 pieces of olmesartan medoxomil tablets consist of the following raw materials according to the weight: 18-22 g of olmesartan medoxomil, 80-120 g of lactose, 30-45 g of microcrystalline cellulose, 30-50 g of low substituted hydroxypropy cellulose, 8-12 g of polylactic acid and 0.5-1.5 g of magnesium stearate. After being tabletted, the components are wrapped by thin film coats; thin film coat liquid is prepared from the following materials: 20 g of opadry and 5 g of polylactic acid and is prepared by dissolving the raw materials in 200 g of ethyl alcohol with the concentration of 80 percent for uniform mixing.

Description

technical field [0001] The invention relates to the field of medicines, in particular to an olmesartan medoxomil tablet and a preparation method. Background technique [0002] The number of deaths from cardiovascular diseases is said to be higher than the sum of the other 7 major causes of death (including cancer and AIDS / HIV infection). Hypertension is one of the most prevalent problems in cardiovascular disease and the focus of new drug developers. Olmesartan medoxomil (olmesartan medoxomil) is an angiotensin Ⅱ (Ag Ⅱ) antagonist antihypertensive drug newly developed by Japan's Sankyo (Sankyo), and it has been listed for the first time in the United States. Olmesartan medoxomil is a substituted imidazole drug, which is significantly superior to other similar products such as losartan, valsartan, and irbesartan in terms of overall efficacy in reducing diastolic blood pressure. It has good drug tolerance and no cough side effects compared with ACE inhibitors, and is an oral...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K31/4178A61K47/34A61P9/12
Inventor 袁淑杰杨新春崔琳李郑武王忠高晶李金花刘磊陆蕊杭
Owner 哈药集团股份有限公司
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