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Sulfadoxine production process

A technology for the production of sulfonamide, which is applied in the field of sulfonamide production, can solve the problems of low yield and achieve high yield

Inactive Publication Date: 2015-02-25
CHANGSHU JINSHEN MEDICAL PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The production technology of existing sulfonamide, yield is low

Method used

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Examples

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Embodiment Construction

[0011] The specific implementation of the present invention will be further described below in conjunction with the examples. The following examples are only used to illustrate the technical solution of the present invention more clearly, but not to limit the protection scope of the present invention.

[0012] The technical scheme of concrete implementation of the present invention is:

[0013] A kind of production technique of sulfonamide, comprises the steps:

[0014] 1) In the presence of solid sodium ethylate, react 15 parts by mass of methyl methoxyacetate with 32.3 parts by mass of diethyl oxalate to generate methylethyl 3-methoxy-2-oxobutanedioate, and further remove Carbonyl, and then recover the low boilers by decompression and fractionation in a fractionating tower. After the low boilers are separated, directly cool the remaining reaction liquid without passing through the fractionating tower to obtain 2-methoxy-malonic acid methyl ethyl alcohol with a purity greate...

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PUM

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Abstract

The invention discloses a sulfadoxine production process. The sulfadoxine production process includes the steps: 1) enabling reaction of methyl methoxyacetate and diethyl oxalate to generate 3-methoxy-2-ethyl oxo-succinate formate; 2) in existence of sodium methoxide, enabling 2-methoxy-ethyl malonate formate to react with formamide, adding water, recovering aqueous methanol, spinning, discharging and drying to obtain a ring compound; 3) enabling the ring compound and phosphoryl chloride to flow back at 65 DEG C, and performing heat reaction for 3 hours to generate 4,6-dichloro-5-methoxy pyrimidine; 4) subjecting the 4,6-dichloro-5-methoxy pyrimidine and aminophenol sulfamide sodium to condensation reaction to generate 4-(sulfanilamide)-5-methoxy-6-chloropyrimidine; 5) putting the 4-(sulfanilamide)-5-methoxy-6-chloropyrimidin into a reaction kettle, adding methanol and solid sodium hydroxide, slowly heating to 60 DEG C, and performing heat reaction for 2.5 hours to obtain a finished sulfadoxine product. The sulfadoxine production process has the advantages of high sulfadoxine production yield.

Description

technical field [0001] The invention relates to a production process of sulfonamide. Background technique [0002] The existing sulfonamide production process has a low yield. Contents of the invention [0003] The purpose of the present invention is to provide a kind of production technology of sulfonamide, which has a high yield of sulfonamide. [0004] For achieving the above object, technical scheme of the present invention is to design a kind of production technique of sulfonamide, comprising the steps: [0005] 1) In the presence of solid sodium ethylate, react 15 parts by mass of methyl methoxyacetate with 32.3 parts by mass of diethyl oxalate to generate methylethyl 3-methoxy-2-oxobutanedioate, and further remove Carbonyl, and then recover the low boilers by decompression and fractionation in a fractionating tower. After the low boilers are separated, directly cool the remaining reaction liquid without passing through the fractionating tower to obtain 2-methoxy-m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D239/69
CPCC07D239/69
Inventor 李涛
Owner CHANGSHU JINSHEN MEDICAL PROD CO LTD
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