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Application of microRNA (ribonucleic acid) has-miR574-3p in hypertension diagnosis

A technology of tiny nucleotides and high blood pressure, applied in the determination/testing of microorganisms, biochemical equipment and methods, etc., can solve the problems of family and country burden, consumption of medical and social resources, high mortality rate, etc.

Active Publication Date: 2015-02-18
YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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  • Abstract
  • Description
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Problems solved by technology

[0004] Hypertension is the most important risk factor for cardiovascular and cerebrovascular diseases. Its major complications such as stroke, myocardial infarction, heart failure and chronic kidney disease not only cause disability and high mortality rate, but also seriously consume medical and social resources. heavy burden on the state

Method used

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  • Application of microRNA (ribonucleic acid) has-miR574-3p in hypertension diagnosis
  • Application of microRNA (ribonucleic acid) has-miR574-3p in hypertension diagnosis
  • Application of microRNA (ribonucleic acid) has-miR574-3p in hypertension diagnosis

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Embodiment 1

[0018] In this implementation plan, the invention mainly expresses the research methods of MIR expression spectrum chips, discusses and clarifies the MIRS expressed in the process of hypertension and the formation of hypertension.This study first reveals the MIRS of the pre -hypertension and the expression changes related to hypertension, which not only helps to more comprehensively clarify the molecular mechanism of hypertension, but also provides a series of new molecular markers for the assessment of the progress of hypertension disease.And provide a series of new MIR -based treatment targets, laying a good foundation for the R & D method of reducing the treatment of blood pressure and hypertension target organs.

[0019] Method

[0020] 1. Clinical research sample collection

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Abstract

The invention relates to an application of microRNA (ribonucleic acid) has-miR574-3p in hypertension diagnosis. The application has the advantages as follows: plasma of hypertension patients in prehypertension and normal people is collected for research on whole-genome miR expression profile, research results show that a series of miRs are related to prehypertension and hypertension, and differentially expressed miRs help to explain the molecular mechanism for hypertension incidence; a molecular marker is provided for progress evaluation of prehypertension and hypertension; a brand new therapeutic target is provided for effective blood pressure control and treatment of prehypertension and hypertension; and meanwhile, an antagonist and a mimic containing a single miR or combining multiple miRs are adopted, and a brand new means is provided for treatment of prehypertension and hypertension.

Description

[0001] This application is on November 26, 2013, the application number 201310605650.4, and the invention and creation name of the "small nucleotide in the application of hypertension diagnosis and preparation of blood pressure drugs". Technical field [0002] The invention involves new uses of micro-nucleotide. Specifically, it is the application of microrna Has-Mir574-3P in the diagnosis of hypertension. Background technique [0003] Hypertension is a chronic disease that is commonly elevated with arterial blood pressure continues to rise into the main manifestation. It refers to arterial compression pressure ≥140mmHg and / or diastolic pressure ≥90mmHg under a static state.The shrinkage pressure at 120-139mmHg and / or diastolic pressure at 80-89mmHg is called the early or normal high value of hypertension. [0004] Hypertension is the main risk factor for cardiovascular and cerebrovascular disease. Its stroke, myocardial infarction, heart failure, and chronic kidney disease and ot...

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q1/6883C12Q2600/136C12Q2600/158C12Q2600/178
Inventor 张腾陈瑜贾成林杨琴波王培伟李黎崔金刚杜宵烨宁冰冰刘丽
Owner YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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