Supplemented culture medium of teicoplanin and method for producing teicoplanin

Abstract

The invention provides a supplemented culture medium of teicoplanin, which is capable of improving the output of teicoplanin and a method for producing the teicoplanin. The supplemented culture medium of the teicoplanin comprises one or more of a carbon source, a nitrogen source and a pH value regulator, wherein the carbon source comprises one or more of glycerol, glucose, starch, oat flour and lactose; the nitrogen source comprises one or more of corn gluten meal, cottonseed fine lour, soybean meal, peptone and yeast powder; and the pH value regulator comprises one or two of phosphoric acid and ammonia water. The method for producing the teicoplanin specifically comprises a step of adding the supplemented culture medium into a fermentation culture medium during fermentation, wherein the supplemented culture medium comprises one or more of the carbon source, the nitrogen source and the pH value regulator. The invention has the beneficial effects that the supplemented culture medium is added into the fermentation culture medium during fermentation to reduce factors inhibiting secondary metabolic pathways for producing the teicoplanin, and the fermentation output of the teicoplanin can be improved.

Description

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AI Technical Summary

Benefits of technology

This patented technology helps reduce problems with producing certain compounds called teicophan by adding an ingredient like yeast extract or other substances into it beforehand when starting up new bacteria for use later on. By doing this, these techniques help prevent unwanted side reactions from affecting specific molecules involved in making Tecrolimus (a drug).

Problems solved by technology

Technological Problems This patented describes challengings associated with improving the efficiency at which tikilosan can produce certain substances like teiocyanolides called TICAOXINS. These new molecules were found earlier than previously identified because they had several advantages over existing ones. However, previous methods did not work well enough on this type of product without adding other ingredients. Therefore, improvements could lead to more effective ways to make teicopyranon from natural materials through gene manipulation techniques.