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Application of Activin B in preparation of medicine for treating neurodegeneration diseases

A neurodegenerative and disease technology, applied in nervous system diseases, drug combinations, pharmaceutical formulations, etc., can solve problems such as failure to achieve ideal therapeutic effects, complex etiology and pathogenesis of Parkinson's disease, and reduce neuronal apoptosis. , No toxic side effects, the effect of reducing inflammatory response

Inactive Publication Date: 2015-02-18
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The etiology and pathogenesis of Parkinson's disease are very complex and have not been fully clarified so far. The current clinical treatment options for Parkinson's disease, including drug therapy, cell replacement therapy and surgical treatment, have failed to achieve the desired therapeutic effect

Method used

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  • Application of Activin B in preparation of medicine for treating neurodegeneration diseases
  • Application of Activin B in preparation of medicine for treating neurodegeneration diseases
  • Application of Activin B in preparation of medicine for treating neurodegeneration diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1. In vitro experiment

[0018] 1.1 Experimental cells : SH-SY5Y cells, cultured in high-glucose DMEM medium containing 1% penicillin and streptomycin and 10% fetal bovine serum. MPP + and Activin B dissolved in normal saline for later use.

[0019] 1.2 Experimental method and grouping : Serum starvation of SH-SY5Y cells for 24 hours, with 25μm / ml MPP + Cells were incubated for 12 hours in the culture medium, and after being replaced with normal medium for 24 hours, they were randomly divided into 4 groups (group ① was MPP + Model group, MPP + After treatment, continue culturing with normal medium for 24 hours; group ② MPP + +Activin B 5ng / ml: MPP + After treatment, culture with medium containing 5ng / ml Activin B for 24h; ③MPP + +Activin B 25ng / ml: MPP + After treatment, culture with medium containing 25ng / ml Activin B for 24h, ④ MPP + +Activin B 50ng / ml: MPP + After treatment, they were cultured with medium containing 50ng / ml Activin B for 24 hours; in t...

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Abstract

The invention discloses an application of Activin B in preparation of medicine for treating neurodegeneration diseases. In vivo and in vitro experimental research shows that Activin B can be used in treatment of the neurodegeneration diseases, can effectively reduce nerve cell apoptosis, increase TH immunoreactive nerve fiber density in a corpus striatum region, reduce the inflammatory response and remarkably increase the rotarod time of a mouse with the Parkinson's disease, the field movement distance and speed; and further, Activin B is basically free of toxic and side effects, is novel medicine which has development prospect and is used for treating the neurodegeneration diseases, and particularly is expected to be developed into novel medicine for treating Parkinson's disease.

Description

technical field [0001] The invention relates to the application of Activin B in the preparation of medicines for treating neurodegenerative diseases. Background technique [0002] Parkinson's disease is the second most common degenerative disease of the nervous system, and its main symptoms are changes in motor function, such as bradykinesia, resting tremor, gait deformity, and postural instability, which eventually lead to loss of motor function. The death of nigrostriatal dopamine neurons is the main pathological feature of Parkinson's disease. [0003] The etiology and pathogenesis of Parkinson's disease are very complex and have not been fully clarified so far. The current clinical treatment options for Parkinson's disease, including drug therapy, cell replacement therapy and surgical treatment, have failed to achieve the desired therapeutic effect. Therefore, finding drugs that can effectively prevent or improve Parkinson's symptoms is the most urgent goal at present. ...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61P25/16A61P25/00
Inventor 张璐张琳李娟薛进华
Owner SOUTHERN MEDICAL UNIVERSITY
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