Method and apparatus for preparing single donor thrombin serum

A thrombin and serum technology, applied in the field of conversion of prothrombin to thrombin, can solve the problem of lack of an ideal method for preparing single-donor thrombin serum, reduce the risk of transmission of infectious diseases, and avoid immunogenic reactions , the effect of avoiding the risk of microbial contamination

Active Publication Date: 2015-02-11
STEM CELL PARTNERS
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  • Abstract
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Problems solved by technology

[0028] Despite these advances, an ideal method for preparing single-donor thrombin serum in the healthcare setting is still lacking

Method used

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  • Method and apparatus for preparing single donor thrombin serum
  • Method and apparatus for preparing single donor thrombin serum
  • Method and apparatus for preparing single donor thrombin serum

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Embodiment Construction

[0064] The purpose of the following description is to enable those of ordinary skill in the art to produce and use various aspects and examples of the present invention. The description of specific materials, technologies and applications is only exemplary. It is obvious to a person of ordinary skill in the art that various modifications can be made to the examples described herein, and the general principles specified herein are also applicable to other examples without departing from the spirit and scope of the present invention. Examples and applications. Therefore, the present invention is not limited to the examples described and shown, and its scope is limited only by the appended claims.

[0065] Please refer first figure 2 , The process in the preferred embodiment of the present invention includes four steps, these steps preferably occur in order: 1) by combining and incubating the first biological fluid with the coagulation cascade ability in the presence of free calci...

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Abstract

A method for preparing thrombin serum, the method comprising obtaining blood fluid sample, contacting a first aliquot of the blood fluid with a procoagulant agent to form prothrombinase enzyme complex bound to the surface of the procoagulant agent so as to obtain an activated procoagulant agent that may be stored. The activated procoagulant agent may then be contacted with a second aliquot of the blood fluid containing prothrombin so as to obtain thrombin serum, which may be extracted and contacted with fibrinogen to obtain fibrin.

Description

[0001] Related application [0002] This patent application is a non-provisional application of U.S. Provisional Patent Application 61 / 705,535 filed on September 25, 2012, and claims the priority of the patent application. The entire content of the patent application is incorporated herein to form an integrated document. Technical field [0003] The present invention relates to the conversion of prothrombin in blood to thrombin, and in particular to a device and method for increasing the concentration of activated cascade coagulation protein in blood. Background technique [0004] Plasma coagulation is considered to be through a series of self-amplifying zymogen-enzyme conversion ( figure 1 ) Occurs, in the penultimate step of this conversion process thrombin (FIIa) is produced, which is a powerful serine protease. In the final step called the "coagulation cascade", prothrombin is converted into thrombin by a calpain-containing complex called prothrombinase complex. Thrombin is an ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/36
CPCA61K38/4833A61P7/04C12Y304/21005F04C2270/0421A61J1/1443A61K35/16A61K47/10
Inventor J.R.查普曼
Owner STEM CELL PARTNERS
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