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Method for preparing high-strength double-network nano silicon dioxide composite hydrogel

A technology of nano-silica and composite hydrogel, applied in the field of preparation of high-strength double-network nano-composite hydrogel, to achieve the effect of improving mechanical strength

Active Publication Date: 2015-01-07
山东济清科技服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Compared with the traditional sodium alginate / polyacrylamide double network hydrogel, it has a greater improvement

Method used

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  • Method for preparing high-strength double-network nano silicon dioxide composite hydrogel
  • Method for preparing high-strength double-network nano silicon dioxide composite hydrogel
  • Method for preparing high-strength double-network nano silicon dioxide composite hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1) Boil distilled water, seal and cool to room temperature to remove oxygen in the water, prepare a mass fraction of 1% nano-SiO with cooled distilled water 2 Aqueous solution, nano-SiO used 2 The particle size is 20-30nm, dispersed evenly by ultrasonic vibration for 10 minutes, and ready for use;

[0033] 2) get sodium alginate and acrylamide to be dissolved in the nano-SiO prepared in step 1) 2 In the aqueous solution, the mass ratio of the sodium alginate to acrylamide is 1:6, and the mass fraction of the total content of sodium alginate and acrylamide is 10%;

[0034] 3) Add N,N'-methylenebisacrylamide, ammonium persulfate, and tetramethylethylenediamine to the solution obtained in step 2), the N,N'-methylenebisacrylamide, persulfate Ammonium sulfate and tetramethylethylenediamine account for 0.03%, 0.1%, and 0.2% of the mass of acrylamide, respectively;

[0035] 4) Transfer the solution prepared in step 3) to a glass mold, seal it, place it at 45°C, and keep it ...

Embodiment 2

[0039] 1) Boil distilled water, seal and cool to room temperature to remove oxygen in the water, and prepare a mass fraction of 10% nano-SiO with cooled distilled water 2 Aqueous solution, nano-SiO used 2 The particle size is 90-100nm, dispersed evenly by ultrasonic vibration for 10 minutes, and ready for use;

[0040] 2) get sodium alginate and acrylamide to be dissolved in the nano-SiO prepared in step 1) 2 In the aqueous solution, the mass ratio of the sodium alginate to acrylamide is 1:6, and the mass fraction of the total content of sodium alginate and acrylamide is 20%;

[0041]3) Add N,N'-methylenebisacrylamide, ammonium persulfate, and tetramethylethylenediamine to the solution obtained in step 2), the N,N'-methylenebisacrylamide, persulfate Ammonium sulfate and tetramethylethylenediamine account for 0.09%, 0.2%, and 0.3% of the mass of acrylamide, respectively;

[0042] 4) Transfer the solution prepared in step 3) to a glass mold, seal it, place it at 55°C, and kee...

Embodiment 3

[0046] 1) The distilled water is boiled and sealed and cooled to room temperature to remove the oxygen in the water, and the mass fraction of 6% nano-SiO is prepared with the cooled distilled water 2 Aqueous solution, nano-SiO used 2 The particle size is 40-50nm, dispersed evenly by ultrasonic vibration for 10 minutes, and ready for use;

[0047] 2) get sodium alginate and acrylamide to be dissolved in the nano-SiO prepared in step 1) 2 In the aqueous solution, the mass ratio of the sodium alginate to acrylamide is 1:6, and the mass fraction of the total content of sodium alginate and acrylamide is 14%;

[0048] 3) Add N,N'-methylenebisacrylamide, ammonium persulfate, and tetramethylethylenediamine to the solution obtained in step 2), the N,N'-methylenebisacrylamide, persulfate Ammonium sulfate and tetramethylethylenediamine account for 0.06%, 0.17%, and 0.25% of the mass of acrylamide, respectively;

[0049] 4) Transfer the solution prepared in step 3) to a glass mold, sea...

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Abstract

The invention discloses a method for preparing high-strength double-network nano silicon dioxide composite hydrogel. The method comprises the following steps: preparing a nano SiO2 water solution by using cooled boiled distilled water, dissolving sodium alginate, acrylamide, a cross-linking agent, an initiator and a catalyst into the SiO2 aqueous solution, rapidly transferring the prepared solution to a glass mold, putting the sealed mold into an environment of 45-55 DEG C, and performing heat-preservation reaction for 2-6 hours; taking out the hydrogel formed inside the mold, soaking the hydrogel in a CaC12 aqueous solution with the concentration of 0.1-1M for 2-6 hours, and taking out the product, thereby obtaining the high-strength double-network nano silicon dioxide composite hydrogel. Compared with the conventional hydrogel, the composite hydrogel disclosed by the invention is relatively high in strength and elongation, and the application demands in human body cartilage repairing, tissue engineering and the like can be met.

Description

technical field [0001] The invention relates to the field of preparation of a high-strength hydrogel, in particular to the preparation of a high-strength double-network nanocomposite hydrogel. technical background [0002] Hydrogel is a kind of macromolecule or macromolecular aggregate with chemical or physical cross-linking structure, which can absorb a large amount of water but is insoluble in water. They can maintain a certain shape and three-dimensional space network structure in water. As a soft material with a water content of up to 90% and very similar to biological soft tissue, hydrogel is widely used in biological and medical fields, such as tissue engineering and cartilage repair. However, the mechanical strength of traditional hydrogels is far lower than that of natural biological tissues, which severely limits the clinical application of hydrogels. Therefore, narrowing the performance gap between polymer hydrogels and biological soft tissues, seeking polymer hyd...

Claims

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Application Information

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IPC IPC(8): C08L33/26C08L5/04C08K3/36C08F220/56C08F222/38C08F222/14C08F212/36C08J7/00C08J3/075C08J3/24
Inventor 王兴建翟云鸽
Owner 山东济清科技服务有限公司
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