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Degradable open-cell porous zinc/zinc alloy biomaterial and preparation method thereof

A biomaterial and zinc alloy technology, applied in the field of degradable open-pore porous zinc and zinc alloy biomaterials and their preparation, to achieve the effects of controllable size, convenient operation, and excellent biocompatibility

Active Publication Date: 2015-01-07
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far there is no research report on porous zinc and zinc alloys as scaffolds for bone tissue engineering

Method used

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  • Degradable open-cell porous zinc/zinc alloy biomaterial and preparation method thereof

Examples

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Effect test

Embodiment 1

[0031] This example relates to a degradable open-pore porous zinc alloy used for bone tissue engineering scaffolds, with a diameter of 55 mm, a height of 50 mm, a spherical pore shape, and a pore diameter of 500-600 μm. The number of interconnected pores contained in the inner wall of a single cavity is 5 to 10, the diameter of the connected pores is 150 μm, and the porosity is 90%. Its structure is as figure 1 As shown, (a) is a schematic diagram of the three-dimensional structure of degradable open-pore porous zinc and zinc alloy bone tissue engineering scaffolds, which accurately reflects the pore characteristics described in the present invention, for example, spherical pore type and interconnected pores The hole type and their distribution characteristics; (b) The picture is the corresponding physical map, from which we can see the spherical hole type and the hole type of the connected holes distributed on the hole wall and their distribution characteristics and schematic...

Embodiment 2

[0037] This embodiment relates to a degradable open-pore porous zinc alloy used for bone tissue engineering scaffolds, with a diameter of 100mm, a height of 100mm, a cubic shape, a pore diameter of 900-1000μm, and the number of interconnected pores contained in the inner wall of a single cavity There are 3 to 5 connected pores, the diameter of the connected pores is 400 μm, and the porosity is 85%.

[0038] This embodiment relates to the aforementioned method for preparing a degradable open-pore porous zinc alloy for bone tissue engineering scaffolds, the method comprising the following steps:

[0039] Step 1, put the cubic sodium chloride crystal particles with a size of 900-1000 μm into a mold with an inner diameter of 100 mm and a height of 100 mm and sinter at a constant temperature of 790 ° C for 24 hours, and then cool with the furnace to obtain an open-pore porous sodium chloride prefabricated body with a certain strength ;

[0040] Step 2, pouring the Zn-3wt%Mg alloy ...

Embodiment 3

[0043] This example relates to a degradable open-pore porous zinc used for bone tissue engineering scaffolds, with a diameter of 200 mm and a height of 200 mm. The pore type is irregular and the pore diameter is 700-750 μm. 3 to 4 pieces, the diameter of the connected pores is 250 μm, and the porosity is 70%.

[0044] This embodiment relates to the preparation method of the aforementioned degradable open-pore porous zinc for bone tissue engineering scaffold, the method comprising the following steps:

[0045] Step 1, put irregular sodium chloride crystal particles with a size of 700-750 μm into a mold with an inner diameter of 200 mm and a height of 200 mm, sinter at a constant temperature of 700 ° C for 10 hours, and cool with the furnace to obtain an open-pore porous sodium chloride prefabricated with a certain strength body;

[0046] Step 2, pouring pure zinc metal melt into the mold cavity with open porous sodium chloride prefabricated body, and carrying out pressure seep...

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Abstract

The invention discloses a degradable open-cell porous zinc / zinc alloy biomaterial and a preparation method thereof. The degradable open-cell porous zinc / zinc alloy biomaterial is of a completely open-cell structure, wherein the hole pattern and the size are controllable, holes are communicated by use of communicating holes, and the number and the size of the communicating holes in the hole walls are controllable; the biomaterial is even in overall hole distribution and adjustable in porosity. The preparation method of the biomaterial comprises the following steps that sodium chloride crystal particles are sintered to obtain an open-cell porous sodium chloride prefabricated structure; a zinc or zinc alloy melt is poured into a die cavity in which a sodium chloride prefabricated body is put and pressure seepage casting is performed; the outer skin of a zinc or zinc alloy block containing the sodium chloride prefabricated body is removed, and then alkali wash is performed and the sodium chloride is performed to obtain the degradable open-cell porous zinc / zinc alloy biomaterial. The preparation method of the degradable open-cell porous zinc / zinc alloy biomaterial is simple in process, convenient to operate and pollution-free; the obtained open-cell porous structure has the advantages that the holes are communicated with each other and distributed evenly, the appearance and size of the holes are controllable, the porosity and the strength are relatively high, no hole forming agent is left and hole closure is prevented, and meanwhile, the degradation rate is adjustable; as a result, the biomaterial can be used as a new generation degradable bone tissue engineering stent.

Description

technical field [0001] The invention belongs to the technical field of preparation of biomedical materials, and relates to a method for designing an open-pore porous material, in particular to a degradable open-pore porous zinc and zinc alloy biomaterial used for bone tissue engineering scaffolds and a preparation method thereof. Background technique [0002] Among the biomedical metal materials, zinc, magnesium and their alloys are considered to be the most attractive at present due to their excellent comprehensive properties, good mechanical properties, biocompatibility and in vivo degradability of biomaterials. One of the biomaterials, it is an alternative material for intraosseous implants, vascular stents, dental implants, etc. The porous biomaterial with a three-dimensional penetrating network structure can effectively induce the growth and regeneration of bone tissue and human tissue, so that the bone implant does not loosen and fall off, and also has the characterist...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/56A61L27/58C22C1/08B22D23/04C22C18/00
Inventor 袁广银贾高智丁文江
Owner SHANGHAI JIAO TONG UNIV
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