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Preparation method of folic acid class nutrient supplement

A folic acid and filler technology, applied in the field of pharmaceuticals, can solve the problems of low folic acid content, poor disintegration and dissolution, unstable properties when exposed to light, etc., and achieve the effect of ensuring uniform distribution, ensuring stability, and stable properties

Inactive Publication Date: 2014-12-24
哈药集团人民同泰医药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the above-mentioned technical problems, the present invention provides a tablet prescription composition and preparation method for supplementing folic acid and iron. Oxidation and other factors lead to technical problems such as uneven product content, poor disintegration and dissolution

Method used

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  • Preparation method of folic acid class nutrient supplement
  • Preparation method of folic acid class nutrient supplement
  • Preparation method of folic acid class nutrient supplement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A tablet for supplementing folic acid and iron. The proportions of each raw and auxiliary material are: 0.4 parts of folic acid, 30.3 parts of ferrous fumarate, 4 parts of sodium carboxymethyl starch, and hydroxypropyl methylcellulose. 2.8 parts, 0.5 parts of magnesium stearate, 112 parts of microcrystalline cellulose, 4 parts of coating powder.

[0037] A tablet for supplementing folic acid and iron, and its specific preparation method is as follows: take ferrous fumarate, microcrystalline cellulose and sodium starch glycolate in parts by weight, pass through a 100-mesh sieve, and place in a three-dimensional mixer Mix for 20 minutes, take the above-mentioned uniformly mixed raw and auxiliary materials out of the three-dimensional mixer, place in the wet granulation mixer, and stir and mix for 2 minutes; dissolve the weight parts of hydroxypropyl methylcellulose in an appropriate amount Purified water is made into an aqueous binder solution with a mass percentage of 6%, a...

Embodiment 2

[0039] A tablet for supplementing folic acid and iron. The proportions of each raw and auxiliary material are respectively: 0.4 parts of folic acid, 30.3 parts of ferrous fumarate, 4.5 parts of sodium carboxymethyl starch, and hydroxypropyl methylcellulose. 3.2 parts, 0.75 parts of magnesium stearate, 111 parts of microcrystalline cellulose, 6 parts of coating powder.

[0040] A tablet for supplementing folic acid and iron, and its specific preparation method is as follows: take ferrous fumarate, microcrystalline cellulose and sodium starch glycolate in parts by weight, pass through a 100-mesh sieve, and place in a three-dimensional mixer Mix for 40 minutes, take the above-mentioned uniformly mixed raw and auxiliary materials out of the three-dimensional mixer, place them in the wet granulation mixer, and stir and mix for 5 minutes; dissolve the hydroxypropyl methylcellulose in an appropriate amount Purified water is made into a binder aqueous solution with a mass percentage of 8...

Embodiment 3

[0042] A tablet for supplementing folic acid and iron. The proportions of each raw and auxiliary material in total are: 0.4 parts of folic acid, 30.3 parts of ferrous fumarate, 5 parts of sodium carboxymethyl starch, and hydroxypropyl methylcellulose. 3.6 parts, 1 part of magnesium stearate, 110 parts of microcrystalline cellulose, 8 parts of coating powder.

[0043] A tablet for supplementing folic acid and iron, and its specific preparation method is as follows: take ferrous fumarate, microcrystalline cellulose and sodium starch glycolate in parts by weight, pass through a 100-mesh sieve, and place in a three-dimensional mixer Mix for 60 minutes, take the above-mentioned uniformly mixed raw and auxiliary materials out of the three-dimensional mixer, place in the wet granulation mixer, and stir and mix for 5 minutes; dissolve the hydroxypropyl methylcellulose in an appropriate amount Purified water is made into a binder aqueous solution with a mass percentage of 10%, and then th...

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Abstract

The invention discloses a preparation method of a folic acid class nutrient supplement. According to the method, folic acid, an iron-containing compound and pharmaceutical adjuvants are evenly mixed together through a special preparation technology and instruments and equipment and prepared into nutrient supplement class tablets which are uniform in content and stable and can decompose quickly to release functional components. With the adoption of the technical scheme, the preparation method has the advantages and effects as follows: two different nutrient elements can be supplemented simultaneously after the nutrient supplement is taken once; the uniformity and the stability of the functional components are guaranteed; the method is simple in technological operation and applicable to industrial production; the content of the folic acid and the content of iron of the nutrient supplement are appropriate, so that the nutrient supplement is applicable to women of childbearing age and pregnant women.

Description

Technical field [0001] The invention relates to a tablet for supplementing folic acid and iron and a preparation method thereof, and belongs to the technical field of medicines. Background technique [0002] Folic acid is one of the B vitamins. It is an essential medicine and an irreplaceable vitamin prescribed by the World Health Organization. With the development of science and the improvement of people's living standards, people are increasingly aware of the importance of folic acid to human health. When folic acid is lacking, it will lead to macrocytic anemia and cardiovascular and cerebrovascular diseases; especially when pregnant women lack folic acid, it will cause serious consequences such as premature birth, mental retardation and malformations. Studies have also found that folic acid is especially important for pregnant women. Lack of folic acid in the first 3 months of pregnancy can lead to defects in fetal neural tube development, thereby increasing the incidence of...

Claims

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Application Information

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IPC IPC(8): A61K33/26A61K9/28A61P3/02A61K31/519
Inventor 刘春凤秦雅英杨大伟李伟
Owner 哈药集团人民同泰医药股份有限公司
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