Compound injection for preventing and treating edema disease of piglet and preparation method of compound injection

A piglet edema disease and injection technology, applied in the field of injection, to achieve the effect of improving survival rate, reducing morbidity, and wide clinical application

Inactive Publication Date: 2014-12-24
TIANJIN JUNHEXIN TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Through comparison, it is found that the composition of the above patent documents is quite different from this patent, and the therapeutic effect is also quite different from this patent.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A compound injection for preventing and treating piglet edema, the composition and parts by weight are as follows:

[0024] Enrofloxacin 13 parts, furosemide 1 part, propylene glycol 120 parts, ethanol 120 parts, water for injection 1000 parts.

[0025] A preparation method of a compound injection for preventing and treating piglet edema, the steps are as follows:

[0026] (1) Take by weight 13 parts of enrofloxacin, 1 part of furosemide, 120 parts of propylene glycol, and 120 parts of ethanol;

[0027] (2) Add the enrofloxacin and furosemide to 150 parts of water for injection, add an appropriate amount of 0.2-4 parts of sodium hydroxide and stir until completely dissolved;

[0028] (3) Propylene glycol and ethanol are mixed and stirred evenly;

[0029] (4) Combine the solution prepared in step (2) and step (3) and stir evenly; adjust the pH to 9.5-10.5 with hydrochloric acid or sodium hydroxide, add water for injection to 1000 parts, and then prepare.

Embodiment 2

[0031] A compound injection for preventing and treating piglet edema, the composition and parts by weight are as follows:

[0032] Compound enrofloxacin injection: 5 parts of enrofloxacin, 1.5 parts of furosemide, 50 parts of propylene glycol, 100 parts of ethanol, and 850 parts of water for injection.

[0033] A preparation method of a compound injection for preventing and treating piglet edema, the steps are as follows:

[0034] (1) Take by weight 5 parts of enrofloxacin, 1.5 parts of furosemide, 50 parts of propylene glycol, and 100 parts of ethanol;

[0035] (2) Add the enrofloxacin and furosemide to 150 parts of water for injection, add an appropriate amount of sodium hydroxide and stir until fully dissolved;

[0036] (3) Propylene glycol and ethanol are mixed and stirred evenly;

[0037] (4) Combine the solution prepared in step (2) and step (3) and stir evenly; adjust the pH to 9.5-10.5 with hydrochloric acid or sodium hydroxide, add water for injection to 1000 parts,...

Embodiment 3

[0039] A compound injection for preventing and treating piglet edema, the composition and parts by weight are as follows:

[0040] 20 parts of enrofloxacin, 5 parts of furosemide, 300 parts of propylene glycol, 300 parts of ethanol, and 400 parts of water for injection.

[0041] A preparation method of compound enrofloxacin injection, the steps are as follows:

[0042] (1) Take by weight 20 parts of enrofloxacin, 5 parts of furosemide, 300 parts of propylene glycol, and 300 parts of ethanol;

[0043] (2) Add the enrofloxacin and furosemide to 150 parts of water for injection, add an appropriate amount of sodium hydroxide and stir until completely dissolved;

[0044] (3) Propylene glycol and ethanol are mixed and stirred evenly;

[0045] (4) Combine the solution prepared in step (2) and step (3) and stir evenly; adjust the pH to 9.5-10.5 with hydrochloric acid or sodium hydroxide, add water for injection to 1000 parts, and then prepare.

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PUM

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Abstract

The invention discloses a compound injection for preventing and treating an edema disease of a piglet and a preparation method of the compound injection. The compound injection comprises the following components in parts by weight: 5-20 parts of enrofloxacin, 0.25-5 parts of furosemide, 50-300 parts of ethanol, 50-300 parts of propylene glycol and 400-900 parts of injection water. The preparation method comprises the following steps: gradually dissolving the components successively; adjusting the pH to be 9.5-10.5 by using hydrochloric acid or sodium hydroxide; and adding injection water to 1,000 parts, thereby preparing the compound injection. The preparation prepared by the preparation method disclosed by the invention is stable, wide in antibacterial spectrum, fast and significant in curative effect, and high in bioavailability. The experiment proves that the curative effect can be enhanced by joint use of enrofloxacin and furosemide, the compound injection is wide in clinical application, can be used as a choice drug for treating the edema disease of the piglet, the survival rate of the piglet is increased, and the morbidity is reduced.

Description

technical field [0001] The invention belongs to the field of injections, in particular to a compound injection for preventing and treating piglet edema and a preparation method thereof. Background technique [0002] Piglet edema disease is an acute and subacute sporadic infectious disease caused by pathogenic Escherichia coli, and the cure rate is low. In recent years, piglet edema disease has been increasing year by year, showing an upward trend. The disease course is short and death is fast. It has become a major obstacle in the current pig industry. When one piglet in a litter becomes ill, it will quickly spread to the whole litter. After the piglets get sick, if the prevention and control measures are not taken in time, the whole litter of piglets will die; the loss is huge. This disease is very harmful to the pig industry. After onset, the preferred drugs are gentamicin and kanamycin. [0003] However, for a long time, due to the abuse of antibiotics, bacterial strai...

Claims

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Application Information

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IPC IPC(8): A61K31/635A61K9/08A61P7/10A61P31/04A61K31/496
Inventor 裴毅
Owner TIANJIN JUNHEXIN TECH DEV
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