High-strength degradable 3D printing material and preparation method thereof

Abstract

The invention provides a high-strength degradable 3D printing material and a preparation method thereof. The high-strength degradable 3D printing material comprises 100 parts of a polyhydroxyalkanoate / hydroxyapatite compound and 0.2-2 parts of white wax oil, wherein the polyhydroxyalkanoate / hydroxyapatite compound comprises polyhydroxyalkanoate and hydroxyapatite with the mass ratio to be 8 to 2. The high-strength degradable 3D printing material has the benefits that the obtained polyhydroxyalkanoate / hydroxyapatite compound is completely degradable, cannot generate acidic metabolites and effectively avoids occurrence of aseptic inflammation complications caused by internal fixation materials clinically at present. At the same time, the hydroxyapatite can effectively improve the mechanical strength of the internal fixation materials and expands the range of application of the internal fixation materials used clinically at present.

Description

technical field [0001] The invention relates to the technical field of medical treatment, in particular to a high-strength degradable 3D printing material and a preparation method thereof. Background technique [0002] 3D printing technology, as an emerging technology in the field of rapid prototyping, is currently becoming a trend of rapid development. The principle is to use layered processing and superposition forming to increase materials layer by layer to generate 3D entities. Without the need for original embryos and molds, objects of any shape can be directly generated by adding materials based on computer graphics data, simplifying product manufacturing. procedures, shorten the product development cycle, improve efficiency and reduce costs. [0003] Fused Extrusion Deposition Molding (FDM) is a commonly used technology in 3D printing technology. The principle is to use thermoplastic polymer materials to extrude from the nozzle in a molten state, solidify to form a...

AI Technical Summary

Problems solved by technology

[0004] Polylactic acid is a commonly used absorbable internal fixation material in orthopedics. It has good biocompatibility, biodegradability and absorbency, and its mechanical strength can support the fracture of hand and foot small joints. It has been recognized as the most effective substitute for metal internal fixation materials. Clinical studies have shown that aseptic inflammatory reactions are one of the main problems faced by absorbable internal fixation materials. The degradation products of PLA materials are acidic small molecules, which have self-catalytic degradation, and the mechanical strength decreases rapidly in vivo. Release more acidic products within a short period of time, exceeding the local clearance capacity of the body, and the accumulation of acidic degradation products will reduce the pH value, prone to adverse reactions