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Self-assembly starch nanoparticle and preparation method thereof

A starch nanometer and self-assembly technology, which can be used in powder transportation, pharmaceutical formulations, cosmetic preparations, etc., can solve a large number of problems, and achieve the effects of simple operation, high spheroidization rate, and narrow particle size distribution

Inactive Publication Date: 2014-12-10
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the process of preparing nanoparticles by the miniemulsion method, the particle size of the prepared nanoparticles is controllable, but a large amount of organic solvents and surfactants are required

Method used

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  • Self-assembly starch nanoparticle and preparation method thereof
  • Self-assembly starch nanoparticle and preparation method thereof
  • Self-assembly starch nanoparticle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 1. Preparation of acid-thinned starch

[0036] Weigh 25g (dry basis) of wheat starch and disperse it in 90% ethanol solution to make starch milk with a concentration of 30%, then add 3mL of concentrated hydrochloric acid, react at 55°C for 1.5h, and use Na 2 CO 3 The solution terminated the reaction, adjusted to neutrality, then rapidly cooled to room temperature, washed, centrifuged, and dried.

[0037] 2. Preparation of esterified starch

[0038] Weigh 15g (dry basis) of the above-mentioned acid-thinned starch in pyridine solution to make a solution with a concentration of 10%, activate it at 95°C for 1.5h under stirring, then add 45g of octenyl succinic anhydride, and continue the reaction at 95°C 3h, after the reaction is completed, cool to room temperature, wash, centrifuge, and dry.

[0039] 3. Preparation of starch nanoparticles

[0040]The inventors found that only starch octenyl succinate with a high degree of substitution can self-assemble into regular and...

Embodiment 2

[0042] 1. Preparation of acid-thinned starch

[0043] Weigh 25g (dry basis) waxy cornstarch and disperse it in 90% ethanol solution to make starch milk with a concentration of 25%, then add 1mL concentrated hydrochloric acid, react at 65°C for 1.5h, and use Na 2 CO 3 The solution terminated the reaction, adjusted to neutrality, then rapidly cooled to room temperature, washed, centrifuged, and dried.

[0044] 2. Preparation of esterified starch

[0045] Weigh 15g (dry basis) of the above-mentioned acid-thinned starch in pyridine solution to make a solution with a concentration of 15%, activate it at 85°C for 2h under stirring, then add 60g of octenyl succinic anhydride, and continue the reaction at 85°C for 2.5 h, after the reaction is completed, cool to room temperature, wash, centrifuge, and dry.

[0046] 3. Preparation of starch nanoparticles

[0047] Weigh 20mg of octenyl succinic acid waxy cornstarch (degree of substitution: 1.02) and dissolve it in 10mL of dimethyl su...

Embodiment 3

[0049] 1. Preparation of acid-thinned starch

[0050] Weigh 25g (dry basis) of cornstarch and disperse it in 50% ethanol solution to make starch milk with a concentration of 10%, then add 2mL of concentrated hydrochloric acid, react at 40°C for 2h, and use Na 2 CO 3 The solution terminated the reaction, adjusted to neutrality, then rapidly cooled to room temperature, washed, centrifuged, and dried.

[0051] 2. Preparation of esterified starch

[0052] Weigh 15g (dry basis) of the above-mentioned acid-thinned starch in pyridine solution to make a solution with a concentration of 20%, activate it at 95°C for 1h under stirring, then add 60g of octenyl succinic anhydride, and continue the reaction at 95°C for 2h , after the reaction is complete, cool to room temperature, wash, centrifuge, and dry.

[0053] 3. Preparation of starch nanoparticles

[0054] Weigh 20 mg of octenyl succinic acid cornstarch (substitution degree is 0.84) and dissolve it in 10 mL of dimethyl sulfoxide ...

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Abstract

The invention discloses a self-assembly starch nanoparticle and a preparation method thereof. According to the method, octenyl succinic acid starch is dissolved in dimethyl sulfoxide solution to obtain a solution A; the degree of substitution of the octenyl succinic acid starch is 0.4-1.5; distilled water is added into the solution A to obtain an octenyl succinic acid starch / dimethyl sulfoxide / water mixed solution system; the volume ratio of solution A to distilled water is 0.5:1 to 2:1; the mixed solution is transferred to a dialysis bag, the dialysis bag is put in dialysate distilled water for dialysis; and impurities in the dialyzed suspension are filtered by use of a microporous filter membrane. The self-assembly starch nanoparticle is free of an emulsifier and organic solvent residue, high in ball forming rate, has a particle size effectively controlled between 50-200nm, and can be used as a carrier for drug and cosmetic active ingredients.

Description

technical field [0001] The invention relates to a starch nanoparticle, in particular to a self-assembled starch nanoparticle and a preparation method thereof. Background technique [0002] Polysaccharide nano-drug loading system has good biocompatibility and biodegradability, and has been widely used in the fields of biology, medicine and pharmaceuticals, such as embedding drugs, proteins, nucleic acids, vaccines, genes, etc. As an important natural polysaccharide, starch not only has a wide range of sources, is cheap, safe and non-toxic, but also has no immunogenicity, good biocompatibility and biodegradability, and is a very potential drug carrier material. [0003] At present, the preparation methods of starch nanoparticles mainly include acid hydrolysis method, nanoprecipitation method and miniemulsion method. The acid hydrolysis method is through HCl, H 2 SO 4 Starch nanocrystals were prepared by acid hydrolysis of starch with other inorganic acids. Although the par...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K9/14A61K8/02A61K8/73C08J3/12C08L3/06C08B31/04
Inventor 高群玉谷峰李秉正
Owner SOUTH CHINA UNIV OF TECH
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