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Compound kanamycin sulfate injection and preparation method

A technology of kanamycin sulfate and injection, which is applied in medical formulas, medical preparations containing active ingredients, drug delivery, etc., can solve problems such as the limitation of bactericidal effect, reduce the probability of drug resistance, reduce the number of medications, and improve the curative effect And the effect

Inactive Publication Date: 2014-12-03
TIANJIN BIJIA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the two are used alone, the bactericidal effect is limited

Method used

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  • Compound kanamycin sulfate injection and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A compound kanamycin sulfate injection, every 1000L injection is made of the following raw materials:

[0021] Lincomycin hydrochloride 30kg, kanamycin sulfate 30kg, aminopyrine 50kg, prednisolone acetate 1kg, 95% ethanol 100L, the rest is water for injection.

[0022] A preparation method of compound kanamycin sulfate injection, the steps are as follows:

[0023] (1) Put aminopyrine and prednisolone acetate into 95% ethanol, stir for 10-25 minutes until clear;

[0024] (2) Get 300L of water for injection, add kanamycin sulfate and lincomycin hydrochloride successively and stir to dissolve;

[0025] (3) Combine the solutions prepared by "(1)" and "(2)", add water for injection to 1000L, stir evenly, keep for 15-20 minutes, and wait for the liquid to become clear.

Embodiment 2

[0027] A compound kanamycin sulfate injection, every 1000L injection is made of the following raw materials:

[0028] Lincomycin hydrochloride 110kg, kanamycin sulfate 110kg, aminopyrine 150kg, prednisolone acetate 20kg, 95% ethanol 400L, the rest is water for injection,

[0029] A preparation method of compound kanamycin sulfate injection, the steps are as follows:

[0030] (1) Put aminopyrine and prednisolone acetate into 95% ethanol, stir for 10-25 minutes until clear;

[0031] (2) Get 300L of water for injection, add kanamycin sulfate and lincomycin hydrochloride successively and stir to dissolve;

[0032] (3) Combine the solutions prepared by "(1)" and "(2)", add water for injection to 1000L, stir evenly, keep for 15-20 minutes, and wait for the liquid to become clear.

Embodiment 3

[0034] A compound kanamycin sulfate injection, every 1000L injection is made of the following raw materials:

[0035] Lincomycin hydrochloride 90kg, kanamycin sulfate 90kg, aminopyrine 100kg, prednisolone acetate 15kg, 95% ethanol 300L, the rest is water for injection,

[0036] A preparation method of compound kanamycin sulfate injection, the steps are as follows:

[0037] (1) Put aminopyrine and prednisolone acetate into 95% ethanol, stir for 10-25 minutes until clear;

[0038] (2) Get 300L of water for injection, add kanamycin sulfate and lincomycin hydrochloride successively and stir to dissolve;

[0039] (3) Combine the solutions prepared by "(1)" and "(2)", add water for injection to 1000L, stir evenly, keep for 15-20 minutes, and wait for the liquid to become clear.

[0040] Clinical Trials:

[0041] 1. Experimental animals:

[0042] Randomly select 100 diseased adult pigs with a body weight of 40-80kg.

[0043] 2. Experimental drug:

[0044] Compound Kanamycin Sul...

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Abstract

The invention relates to a compound kanamycin sulfate injection and its preparation method. The composition of the compound kanamycin sulfate injection and its preparation steps are as follows: (1) aminopyrine and prednisolone acetate are put into 95% ethanol, and stirring is carried out for 10-25 min until the solution is clear; (2) 300L of injection water is taken, and kanamycin sulfate and lincomycin hydrochloride are successively added and stirred until dissolved; and (3) solutions prepared in the steps (1) and (2) are merged, injection water is added to 1000L, the solution is uniformly stirred, and standing lasts for 15-20 min until the liquid medicine is clear. A compound preparation of kanamycin sulfate and lincomycin hydrochloride is adopted, and aminopyrine and prednisolone acetate which have efficacy of adjuvant therapy are added. With combined utilization of the above four medicines, the compound kanamycin sulfate injection has an antibacterial effect on Gram-negative bacteria and Gram-positive bacteria, has wide antibacterial spectrum to widen antimicrobial range, can comprehensively cure swine paratyphoid and some complications and has high and fast curative effects. By the use of the compound kanamycin sulfate injection, drug resistance probability of bacteria is minimized, and curative effect is enhanced.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a compound kanamycin sulfate injection and a preparation method thereof. Background technique [0002] Porcine paratyphoid fever is a common infectious disease of pigs. It poses a great threat to the pig industry. It is often the focus of prevention and treatment of piglet diarrhea in winter. If it cannot be diagnosed and treated or due to wrong diagnosis, it will often bring great losses to the pig industry. . [0003] Porcine paratyphoid disease is characterized by septicemia and chronic necrotic enteritis. The main pathogenic bacteria of the disease are Salmonella, and the bacteria causing porcine paratyphoid fever mainly include Salmonella choleraesuis and Salmonella typhi suis, both of which are Gram-negative bacteria. It has strong adaptability to dry and other environments, and can survive for several weeks or months in the external environment of pigs. [0004] In rec...

Claims

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Application Information

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IPC IPC(8): A61K31/7056A61K9/08A61P31/04A61K31/7036A61K31/573A61K31/4152
Inventor 张伟
Owner TIANJIN BIJIA BIOTECH
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