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Multilayer hollow casein-based submicrometer composite microcapsule and preparation method thereof

A technology of composite microcapsules and empty cheese, which is applied in the direction of microcapsule preparation, microsphere preparation, coating, etc., can solve the problems such as no public reports, and achieve the effect of strong coating and sustained release, and good application potential

Inactive Publication Date: 2014-11-19
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are few public reports on the research on casein-based microcapsules
So far, there have been no public reports on the preparation of hybrid microcapsules by introducing nanoparticles into casein

Method used

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  • Multilayer hollow casein-based submicrometer composite microcapsule and preparation method thereof
  • Multilayer hollow casein-based submicrometer composite microcapsule and preparation method thereof

Examples

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preparation example Construction

[0027] A preparation method of multilayer hollow casein-based submicron composite microcapsules, specifically comprising the following steps:

[0028] Step 1: Prepare lye with a mass fraction of 2% to 4%. The lye is any one of sodium carbonate aqueous solution, triethanolamine aqueous solution or sodium bicarbonate aqueous solution, and then add casein powder. Casein can be food grade, Industrial grade and refined first grade casein powder can be dissolved in alkaline solution, the mass ratio of casein to lye is 1:10~20, after ultrasonic treatment for 5min~20min, stir and dissolve at 50℃~100℃ 24h~48h, obtain casein solution;

[0029]Step 2: Dissolving amphiphilic copolymer micelles Pluronic F127 or P123 in tetrahydrofuran to form a homogeneous transparent solution, the mass-volume ratio of amphiphilic copolymer micelles to tetrahydrofuran is (9~15)g:(90~180)mL, After stirring for 8-14 hours, add the nanoparticle precursor and sonicate for 25min-80min. The mass-volume ratio of...

Embodiment 1

[0033] Step 1: Prepare 20 g of a weak base solution with a mass fraction of 2%, add 1 g of casein powder therein, ultrasonicate for 5 min, and stir at 50° C. for 24 h to obtain a casein solution;

[0034] Step 2: Dissolve 90 mg of amphiphilic copolymer micelles F127 in 900 μL of tetrahydrofuran to form a homogeneous transparent solution. After stirring for 8 hours, add 85 μL of tetraethyl orthosilicate to it and sonicate for 25 minutes to obtain a mixed solution;

[0035] Step 3: Use a micro-syringe to slowly and uniformly inject the mixed solution obtained in step 2 into the casein solution obtained in step 1 at a speed of 800 rpm under high-speed stirring according to the mass ratio of the mixed solution to the casein solution of 1:20 In a container, the mixture was continuously stirred at 60° C. for 4 days, and the tetrahydrofuran was evaporated to dryness to obtain multilayer hollow casein-based submicron composite microcapsules.

Embodiment 2

[0037] Step 1: Prepare 40 g of a weak base solution with a mass fraction of 4%, add 4 g of casein powder therein, ultrasonicate for 20 min, and stir at 100° C. for 48 h to obtain a casein solution;

[0038] Step 2: Dissolve 150 mg of amphiphilic copolymer micelles F127 in 1800 μL of tetrahydrofuran to form a homogeneous transparent solution. After stirring for 14 hours, add 140 μL of methyl orthosilicate to it and sonicate for 80 minutes to obtain a mixed solution;

[0039] Step 3: Using a micro-syringe, the mass ratio of the mixed solution to the casein solution is 1:10. Slowly and uniformly inject the mixed solution obtained in step 2 into the casein solution obtained in step 1 at a speed of 600 rpm under high-speed stirring. In a liquid container, the mixture was continuously stirred at 80°C for 8 days, and the tetrahydrofuran was evaporated to dryness to obtain multilayer hollow casein-based submicron composite microcapsules.

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Abstract

The invention discloses a multilayer hollow casein-based submicrometer composite microcapsule. The microcapsule has a three-layer hollow structure with the particle size of 0.5-1.0mu m, an organic phase and an inorganic phase are distributed at an interval, wherein a core layer is amphiphilic copolymer micelle, a middle layer is nanoparticles, a case layer is casein, and the diameter of the hollow cavity is 0.2-0.3mu m; a preparation method comprises the following steps: dissolving casein into an alkaline solution to obtain a casein dissolution solution, then dissolving the amphiphilic copolymer micelle into an organic solvent, adding a nanoparticle precursor to obtain a mixed solution, finally injecting the casein dissolution solution into the high-speed stirring casein dissolution solution, and reacting to obtain the multilayer hollow casein-based submicrometer composite microcapsule. The prepared microcapsule has better biocompatibility, size regularity and larger cavity structure, stronger cladding and controlled-release action to activated substances, and certain film forming performance, thus being capable of obtaining casein-based composite microcapsule emulsion, and having better application potential on the aspect of a biocompatible functional coating material.

Description

technical field [0001] The invention belongs to the technical field of microcapsule preparation. The invention relates to a multilayer hollow casein-based submicron composite microcapsule, and also relates to a preparation method of a multilayer hollow casein-based submicron composite microcapsule. Background technique [0002] The development technology of microcapsules, that is, micro-containers or packages with polymer walls developed from polymer materials to encapsulate and coat tiny solid particles, liquid droplets or air bubbles, so that it becomes a coating material technology. In the 1940s, it was first successfully applied in the preparation of carbonless copy paper. After the 1970s, microcapsules capable of timed release of drugs were prepared by using microcapsule technology, which greatly promoted the development of microcapsule technology. With the development of science and technology, the preparation methods of microcapsules are also constantly emerging and d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L89/00C08K3/36C08K3/22B01J13/02C09D189/00C09D7/12
Inventor 徐群娜马建中张帆
Owner SHAANXI UNIV OF SCI & TECH
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